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Merck

F2379

Fetuin from fetal calf serum

lyophilized powder, suitable for cell culture

Sinónimos:

Fetuin from fetal calf serum

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About This Item

Número CAS:
9014-81-7
UNSPSC Code:
12352202
EC Number:
232-762-7
NACRES:
NA.61
MDL number:
MFCD00131055

Nombre del producto

Fetuin from fetal calf serum, lyophilized powder, suitable for cell culture

biological source

bovine serum (fetal)

form

lyophilized powder

technique(s)

cell culture | mammalian: suitable

impurities

≤0.3% free N-acetylneuraminic acid

solubility

H2O: 1 mg/mL, colorless to faint yellow or tan

UniProt accession no.

Q58D62

storage temp.

2-8°C

Quality Level

200

Gene Information

bovine ... FETUA(504615)

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Application

Fetuin from fetal bovine serum has been used:
  • to synthesize primary and secondary calciprotein particles (CPP)
  • to study the binding of Xerocomus chrysenteron lectin (XCL) to the T antigen expressed by membrane proteins
  • as a supplement in Ham′s F10 media for myoblast culture.

Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.

Biochem/physiol Actions

Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism. It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases. Fetuin has anti-inflammatory property.

General description

Fetuin from fetal bovine serum is a 64 kDa plasma glycoprotein. It is produced by the liver and adipose tissue.

Preparation Note

Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000514224
0000514223
0000514223
0000514224
0000497993

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A protein nanocontainer targeting epithelial cancers: rational engineering, biochemical characterization, drug loading and cell delivery
Ladurantie C, et al.
Nanoscale, 11(7), 3248-3260 (2019)
mTORC1 regulates mitochondrial integrated stress response and mitochondrial myopathy progression
Khan NA, et al.
Cell Metabolism, 26(2), 419-428 (2017)
Cellular clearance and biological activity of calciprotein particles depend on their maturation state and crystallinity
Koeppert S, et al.
Frontiers in Immunology, 9, 1991-1991 (2018)
Pietro Allevi et al.
Journal of chromatography. A, 1212(1-2), 98-105 (2008-10-28)
The present report describes a method for the quantification of N-acetyl- and N-glycolylneuraminic acids without any derivatization, using their (13)C(3)-isotopologues as internal standards and a C(18) reversed-phase column modified by decylboronic acid which allows for the first time a complete
Kevan L Hartshorn et al.
American journal of physiology. Lung cellular and molecular physiology, 298(1), L79-L88 (2009-10-20)
Collectins are collagenous lectins present in blood, respiratory lining fluid, and other mucosal secretions that play important roles in innate defense against infection. The collectin, surfactant protein D (SP-D), limits infection by viruses and bacteria in the respiratory tract, eye
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Product Information Sheet - F2379

Product Information Sheet

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