FLAAS

Adenosine 5′-triphosphate (ATP) disodium salt hydrate

Name: Adenosine 5′-triphosphate (ATP) disodium salt hydrate
Brand: SIGMA

≥90%, bacterial (Corynebacterium sp), lyophilized powder

Sinónimos:

ATP disodium hydrate

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About This Item

Fórmula lineal:

C₁₀H₁₄N₅O₁₃P₃Na₂ · xH₂O

Número CAS:

34369-07-8

Peso molecular:

551.14 (anhydrous basis)

UNSPSC Code:

12352202

eCl@ss:

32160414

PubChem Substance ID:

24895005

NACRES:

NA.26

EC Number:

213-579-1

MDL number:

MFCD00150755

Nombre del producto

Adenosine 5′-triphosphate (ATP) disodium salt hydrate, vial of ~1 mg ATP

SMILES string

Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

biological source

bacterial (Corynebacterium sp)

assay

≥90%

form

lyophilized powder

packaging

vial of ~1 mg ATP

solubility

water: soluble, clear, colorless (1 vial + 0.1 mL)

storage temp.

−20°C

Quality Level

200

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Categorías relacionadas

Phosphates

Proteins & Enzymes

Detection Substrates & Enzymes

Application

Adenosine 5′-triphosphate (ATP) disodium salt hydrate has been:

used as a standard to measure ATP by bioluminescence method
used in kinase buffer to assess the interaction between death-associated protein kinases (DAPK2) and 14-3-3-β
used as a standard in ATP colorimetric assay

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is one of the nucleoside triphosphate present in living system. It controls various biologic processes such as glucose metabolism, muscle contraction and neurotransmission. Apart from this, ATP serves as an important energy source for the cell. Administration of ATP might be useful in the treatment of non-small-cell lung cancer.

Adenosine 5′-triphosphate was shown to have inhibitory effects on the inflammatory response by abrogating secretion of TNF-α and promoting secretion of Interleukin-10.

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems

Preparation Note

Each vial contains ~1.2 mg of Na₂ATP • 3H₂O equivalent to ~1.0 mg of ATP (2.0 μmol). Actual amount printed on the label.

Prepared to be substantially vanadium-free.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

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Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood.

Els L R Swennen et al.

European journal of immunology, 35(3), 852-858 (2005-02-19)

In vitro studies suggest that extracellular nucleotides and nucleosides may be important regulators of inflammatory and immune responses. Most studies with adenosine 5'-triphosphate (ATP) have been performed in cell lines, which are remote from the human situation. The purpose of

Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia--ischemia

Chavez-Valdez R, et al.

Neuroscience, 219, 192-203 (2012)

Identification of novel death-associated protein kinase 2 interaction partners by proteomic screening coupled with bimolecular fluorescence complementation

Geering B, et al.

Molecular and Cellular Biology, 36(1), 132-143 (2016)

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

Jie Ge et al.

Journal of medicinal chemistry, 49(15), 4606-4615 (2006-07-21)

17-Allylamino-17-demethoxygeldanamycin (17-AAG)1 is a semisynthetic inhibitor of the 90 kDa heat shock protein (Hsp90) currently in clinical trials for the treatment of cancer. However, 17-AAG faces challenging formulation issues due to its poor solubility. Here we report the synthesis and

Allosteric inhibitors of Bcr-abl-dependent cell proliferation.

Francisco J Adrián et al.

Nature chemical biology, 2(2), 95-102 (2006-01-18)

Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized at the molecular level by the expression of Bcr-abl, a 210-kDa fusion protein with deregulated tyrosine kinase activity. Encouraged by the clinical validation of Bcr-abl as the target for the treatment

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