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Merck

G1501

L-Glutamic acid potassium salt monohydrate

≥99% (HPLC), powder

Sinónimos:

MPG, Monopotassium glutamate, Potassium 2-amino-5-hydroxy-5-oxopentanoate, (S)-2-Aminopentanedioic acid, L-α-Aminoglutaric acid potassium salt, L-2-Aminopentanedioic acid potassium salt, Glu, Potassium L-glutamate

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Fórmula empírica (notación de Hill):
C5H8KNO4 · H2O
Número CAS:
6382-01-0
Peso molecular:
203.23
MDL number:
MFCD00150343
UNSPSC Code:
12352209
PubChem Substance ID:
24895063
NACRES:
NA.32
Beilstein/REAXYS Number:
3637377

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Nombre del producto

L-Glutamic acid potassium salt monohydrate, ≥99% (HPLC), powder

SMILES string

O.[K+].N[C@@H](CCC([O-])=O)C(O)=O

InChI

1S/C5H9NO4.K.H2O/c6-3(5(9)10)1-2-4(7)8;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2/q;+1;/p-1/t3-;;/m0../s1

InChI key

XIBUKSQTWSKJMQ-QTNFYWBSSA-M

assay

≥99% (HPLC)

form

powder

color

white

Quality Level

300

Gene Information

human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)
mouse ... GRIK1(14805), GRIK2(14806), GRIK3(14807), GRIK4(110637), GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)
rat ... GRIK1(29559), GRIK2(54257), GRIK3(298521), GRIK4(24406), GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)

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Categorías relacionadas

Application

L-Glutamic acid potassium salt monohydrate has been used-
  • A component of MEM non-essential amino acids solution in cell culture.
  • For the purification of tubulins from bovine brain.
  • In stock solution for the preparation of quenching buffer during the formationof dual-color polarity-marked fluorescent microtubule seeds.
  • The preparation of cell free extracts devoid of RF2 (release factor 2) from Escherichia coli strains.
  • preparation of stock solutions during culture of Arabidopsis plants.

Biochem/physiol Actions

Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.
L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Huntington′s disease and Parkinson′s disease. Glutamate is also responsible for the activation of long-term potentiation (LTP) and long-term depression (LTD). Induction of glutamate receptors plays a key role in the pathophysiology of migraine.

Features and Benefits

Our highly purified L-Glutamic acid potassium salt monohydrate will support your purification or preparation neuropathological diseases research needs

General description

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors. Potassium -glutamate is also used as a component of MEM non-essential amino acids solution in cell culture.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000523080
0000523080
0000519799
0000519797
0000519798

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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

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E D Brenner et al.
Plant physiology, 124(4), 1615-1624 (2000-12-15)
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are the predominant neuroreceptors in the mammalian brain. Genes with high sequence similarity to animal iGluRs have been identified in Arabidopsis. To understand the role of Arabidopsis glutamate receptor-like (AtGLR) genes
Miho Katsuki et al.
Methods in molecular biology (Clifton, N.J.), 777, 117-126 (2011-07-21)
Assaying microtubule dynamics in vitro requires stabilized nucleation centers, a method to immobilize individual microtubules onto a surface, and a specialized microscope to image the microtubule. Microtubules are polar structures with different dynamic properties at the plus and minus ends.
Nitin Shirole et al.
Journal of visualized experiments : JoVE, (48)(48), doi:10-doi:10 (2011-03-16)
Recently, structural and biochemical studies have detailed many of the molecular events that occur in the ribosome during inhibition of protein synthesis by antibiotics and during nascent polypeptide synthesis. Some of these antibiotics, and regulatory nascent polypeptides mostly in the
B K Day et al.
Journal of neurochemistry, 96(6), 1626-1635 (2006-01-31)
L-glutamate (Glu) is the predominant excitatory neurotransmitter in the mammalian central nervous system. It plays major roles in normal neurophysiology and many brain disorders by binding to membrane-bound Glu receptors. To overcome the spatial and temporal limitations encountered in previous
Martina Curto et al.
The journal of headache and pain, 17, 47-47 (2016-05-01)
Activation of glutamate (Glu) receptors plays a key role in the pathophysiology of migraine. Both NMDA and metabotropic Glu receptors are activated or inhibited by metabolites of the kynurenine pathway, such as kynureninic acid (KYNA), quinolinic acid (QUINA), and xanthurenic
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