G1626

L-Glutamic acid monosodium salt hydrate

Name: <SC>L</SC>-Glutamic acid monosodium salt hydrate
Brand: SIGMA

≥99% (HPLC), powder

Sinónimos:

(S)-2-Aminopentanedioic acid, L-Glutamic acid monosodium salt, Glu, MSG, Monosodium glutamate

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About This Item

Fórmula empírica (notación de Hill):

C₅H₈NNaO₄ · xH₂O

Número CAS:

142-47-2

Peso molecular:

169.11 (anhydrous basis)

MDL number:

MFCD00013074

UNSPSC Code:

12352209

PubChem Substance ID:

24895069

NACRES:

NA.32

Nombre del producto

L-Glutamic acid monosodium salt hydrate, ≥99% (HPLC), powder

SMILES string

[NaH].NC(CCC(=O)O)C(=O)O.O

InChI

1S/C5H9NO4.Na.H2O.H/c6-3(5(9)10)1-2-4(7)8;;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2;

InChI key

JYDGDQPVBSBYRT-UHFFFAOYSA-N

assay

≥99% (HPLC)

form

powder

color

white to off-white

Quality Level

300

Gene Information

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Application

L-Glutamic acid monosodium salt hydrate has been used-

as a chemical modulator to rat hippocampal slice cultures for the study of microglial movement post spreading depression (SD) prior to migraine
as an additive to Neurobasal medium for the growth of embryonic neurons obtained from pregnant mice
as a component of GYE (glucose yeast extract) solid medium for the growth of four strains of phytopathogen Xylella fastidiosa namely, CVC clone 9a5c, Temecula (Pierce′s disease), Jab1 (Coffee Leaf Scorch), and the isolate 6747 (Plum Leaf Scald), which causes diseases in important crop plants
as a component of the stock solution for the equilibration of intracellular and extracellular [H⁺] in segmental nerves obtained from the ventral ganglion of Drosophila larvae
as a supplement to RPMI (Roswell Park Memorial Institute) medium 1640 used to maintain K562 cell cultures with twice-weekly passage

Biochem/physiol Actions

Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.

L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Huntington′s disease and Parkinson′s disease. Glutamate is also responsible for the activation of long-term potentiation (LTP) and long-term depression (LTD). Induction of glutamate receptors plays a key role in the pathophysiology of migraine.

General description

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

0000502661

0000491598

0000485531

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Serum-free media for neural cell cultures.

Price, P J, and Gregory J. B

Protocols for Neural Cell Culture, 255-264 (2001)

Genetically encoded pH-indicators reveal activity-dependent cytosolic acidification of Drosophila motor nerve termini in vivo.

Adam J Rossano et al.

The Journal of physiology, 591(7), 1691-1706 (2013-02-13)

All biochemical processes, including those underlying synaptic function and plasticity, are pH sensitive. Cytosolic pH (pH(cyto)) shifts are known to accompany nerve activity in situ, but technological limitations have prevented characterization of such shifts in vivo. Genetically encoded pH-indicators (GEpHIs)

Growth optimization procedures for the phytopathogen Xylella fastidiosa.

João Carlos Campanharo et al.

Current microbiology, 46(2), 99-102 (2003-01-10)

For the first time, growth curves are shown for the phytopathogen Xylella fastidiosa on traditional growth media such as PW (periwinkle wilt), BCYE (buffered charcoal yeast extract), and on new ones such as GYE (glutamate yeast extract) and PYE (phosphate

Amino acid transamination is crucial for ischaemic cardioprotection in normal and preconditioned isolated rat hearts--focus on L-glutamate.

Bo Løfgren et al.

Experimental physiology, 95(1), 140-152 (2009-09-01)

We have found that cardioprotection by l-glutamate mimics protection by classical ischaemic preconditioning (IPC). We investigated whether the effect of IPC involves amino acid transamination and whether IPC modulates myocardial glutamate metabolism. In a glucose-perfused, isolated rat heart model subjected

Acidic polyamino acids inhibit human eosinophil granule major basic protein toxicity. Evidence of a functional role for ProMBP.

R L Barker et al.

The Journal of clinical investigation, 88(3), 798-805 (1991-09-01)

Eosinophil granule major basic protein (MBP), a potent toxin for helminths and mammalian cells in vitro, is a single polypeptide chain rich in arginine. MBP has been localized on damaged helminths and tissues in hypersensitivity diseases including bronchial asthma. The

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