G8168

G418 disulfate salt

Name: G418 disulfate salt
Brand: SIGMA

solution, non-animal origin, suitable for cell culture, BioReagent

Sinónimos:

Antibiótico G418

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):

C₂₀H₄₀N₄O₁₀ · 2H₂SO₄

Número CAS:

108321-42-2

Peso molecular:

692.71

MDL number:

MFCD00058314

UNSPSC Code:

12352207

PubChem Substance ID:

24895333

NACRES:

NA.76

Nombre del producto

G 418 disulfate salt solution, 50 mg/mL in H₂O, 0.1 μm filtered, BioReagent, suitable for cell culture

SMILES string

OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](OC[C@@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H]([C@H](C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O

InChI

1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1

InChI key

UHEPSJJJMTWUCP-NKCAIAFTSA-N

biological source

Micromonospora echinospora

sterility

0.1 μm filtered

product line

BioReagent

form

solution

potency

50-60 mg per mL

mol wt

692.7

packaging

pkg of 10 and 100 mL

concentration

50 mg/mL in H₂O

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

colorless

solubility

H₂O: 50 mg/mL, clear

antibiotic activity spectrum

parasites

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

200

¿Está buscando productos similares? Visita Guía de comparación de productos

Categorías relacionadas

Suplementos y reactivos para cultivo celular

Disclaimer

El producto es estable durante dos años cuando se conserva entre 2 y 8°C.

General description

Estructura química: aminoglucósido

Application

La disulfato de G418 es un antibiótico aminoglucósido similar en estructura a la gentamicina utilizada para la selección y el mantenimiento de células procariotas y eucariotas. Las concentraciones óptimas para la selección y el mantenimiento varían en función de las líneas celulares. Las bacterias y las algas requieren 5 μg/ml o menos mientras que las células animales pueden requerir de 300 a 500 μg/ml.

Biochem/physiol Actions

Modo de acción: El G418 bloquea la síntesis de polipéptidos y el alargamiento de proteínas al inhibir la síntesis en los ribosomas 70S y 80S.

Espectro antimicrobiano: El G418 selecciona células establemente transfectadas con una construcción de promotor iNOS y gen de resistencia a la neomicina, y muestra actividad contra protozoos y helmintos.

pictograms

GHS08

signalword

Danger

hcodes

H317,H334

pcodes

P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Clase de almacenamiento

12 - Non Combustible Liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Single-gene imaging links genome topology, promoter-enhancer communication and transcription control.

Jieru Li et al.

Nature structural & molecular biology, 27(11), 1032-1040 (2020-09-23)

Transcription activation by distal enhancers is essential for cell-fate specification and maintenance of cellular identities. How long-range gene regulation is physically achieved, especially within complex regulatory landscapes of non-binary enhancer-promoter configurations, remains elusive. Recent nanoscopy advances have quantitatively linked promoter

Complement Receptor 2 Based Immunoassay Measuring Activation of the Complement System at C3-Level in Plasma Samples From Mice and Humans.

Lene Halkjær et al.

Frontiers in immunology, 11, 774-774 (2020-05-21)

We aimed at establishing a sensitive and robust assay for estimation of systemic complement activation at complement component C3 level in mouse and human plasma samples. In order to capture the activation products iC3b and C3dg in a specific and

CEACAMs serve as toxin-stimulated receptors for enterotoxigenic Escherichia coli.

Alaullah Sheikh et al.

Proceedings of the National Academy of Sciences of the United States of America, 117(46), 29055-29062 (2020-11-04)

The enterotoxigenic Escherichia coli (ETEC) are among the most common causes of diarrheal illness and death due to diarrhea among young children in low-/middle-income countries (LMICs). ETEC have also been associated with important sequelae including malnutrition and stunting, placing children

Cell-based high-throughput screen for small molecule inhibitors of Bax translocation.

Kelvin Kai-Wan Hui et al.

Journal of cellular and molecular medicine, 23(3), 1784-1797 (2018-12-15)

Aberrant regulation of programmed cell death (PCD) has been tied to an array of human pathologies ranging from cancers to autoimmune disorders to diverse forms of neurodegeneration. Pharmacologic modulation of PCD signalling is therefore of central interest to a number

Functional characterization of two novel non-synonymous alterations in CD46 and a Q950H change in factor H found in atypical hemolytic uremic syndrome patients.

Frida C Mohlin et al.

Molecular immunology, 65(2), 367-376 (2015-03-04)

Atypical hemolytic uremic syndrome (aHUS) is a disease of complement dysregulation, characterized by hemolytic anemia, thrombocytopenia and acute renal failure. Mutations in complement inhibitors are major risk factors for development of aHUS. The three aHUS patients reported in this study

Ver todos los artículos relacionados

Contenido relacionado

Product Information Sheet

G 418 disulfate salt (G1279)

Product Information Sheet - G8168