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Merck

H0888

Hydrocortisone

BioReagent, suitable for cell culture

Sinónimos:

11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M

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About This Item

Fórmula empírica (notación de Hill):
C21H30O5
Número CAS:
50-23-7
Peso molecular:
362.46
UNSPSC Code:
12352209
NACRES:
NA.77
PubChem Substance ID:
24895415
EC Number:
200-020-1
Beilstein/REAXYS Number:
1354819
MDL number:
MFCD00011654
biological source:
soybean
form:
powder
assay:
≥98%

Nombre del producto

Hydrocortisone, BioReagent, suitable for cell culture

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

biological source

soybean

product line

BioReagent

assay

≥98%

form

powder

technique(s)

cell culture | mammalian: suitable

mp

211-214 °C (lit.)

solubility

chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to very faintly yellow

shipped in

ambient

storage temp.

room temp

Quality Level

200

Gene Information

human ... ABCB1(5243), CYP3A4(1576), NR3C1(2908), SERPINA6(866)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126)
rat ... Ar(24208), Nr3c1(24413)

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Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.
Hydrocortisone (also referred to as cortisol) is an endogenous glucocorticoid which is secreted by the adrenal gland. It is produced from the hypothalamus–pituitary–adrenal (HPA) axis. Hydrocortisone interacts with glucocorticoid receptors and regulates various signaling pathways. It is associated with the induction of energy mobilization, increase in cerebral perfusion rates and local glucose consumption. It is also linked with increase in cardiovascular output and respiration, redistribution of blood, delivery of molecules and energy to the brain and muscles and modulation of immune responses.
Primary glucocorticoid secreted by the adrenal cortex.

Application

Hydrocortisone has been used as a supplement in culture media for oligodendrocytes, colon cells and epithelial cells.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Preparation Note

To prepare 50 μg/mL stock solution, add 1.0 mL absolute ethanol to 1.0 mg of product, gently swirl to dissolve, add 19 mL sterile medium.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Repr. 1A - STOT RE 2

target_organs

Adrenal gland,Bone marrow

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
0000453896
0000453896
0000490374
0000490374
0000453895

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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Immunomodulation in septic shock: hydrocortisone differentially regulates cytokine responses.
Briegel J et al.
Journal of the American Society of Nephrology, 12, S70-S70 (2001)
The cortisol awakening response (CAR): facts and future directions.
Fries E et al.
International Journal of Psychophysiology, 72, 67-67 (2009)
Human colon tissue in organ culture: preservation of normal and neoplastic characteristics.
Dame MK et al.
In Vitro Cellular & Developmental Biology. Animal, 46, 114-114 (2010)
A J Kent et al.
Biomaterials, 218, 119337-119337 (2019-07-22)
Laminin-111 (Ln-1), an extracellular matrix (ECM) glycoprotein found in the basement membrane of mammary gland epithelia, is essential for lactation. In mammary epithelial cells (MECs), dystroglycan (Dg) is believed to be necessary for polymerization of laminin-111 into networks., thus we
Bettina Gerstner et al.
Journal of neuroscience research, 87(9), 2078-2086 (2009-02-19)
Developing oligodendrocytes (pre-OLs) are highly vulnerable to hypoxic-ischemic injury and associated excitotoxicity and oxidative stress. 17beta-Estradiol plays an important role in the development and function of the CNS and is neuroprotective. The sudden drop in circulating estrogen after birth may
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