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H4914

Honokiol

Name: Honokiol
Brand: SIGMA

≥98% (HPLC), Antiangeogenic reagent, powder

Sinónimos:

5,3′-Diallyl-2,4′-dihydroxybiphenyl, NSC 293100

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Fórmula empírica (notación de Hill):

C₁₈H₁₈O₂

Número CAS:

35354-74-6

Peso molecular:

266.33

UNSPSC Code:

12352200

PubChem Substance ID:

24724501

NACRES:

NA.77

MDL number:

MFCD00016674

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Propiedades

Nombre del producto

Honokiol, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

solubility

DMSO: 36 mg/mL

antibiotic activity spectrum

Gram-positive bacteria, neoplastics

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

Oc1ccc(cc1CC=C)-c2cc(CC=C)ccc2O

InChI

1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2

InChI key

FVYXIJYOAGAUQK-UHFFFAOYSA-N

Descripción

General description

Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.

Application

Honokiol has been used:

to study its effects on plasmid hSirt3^102-399 deacetylation activity
as an antioxidant to study its cytoprotective role in human ovarian cancer cells (SKOV-3) and Chinese hamster ovary cells (CHOK1)
to explore its effects on oxidative stress and mitochondrial dysfunction via a sirt3-dependent manner
for intracerebroventricular (ICV) cannulation

Biochem/physiol Actions

Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.