H5915
2,3-Bis(4-hydroxyphenyl)propionitrile
≥98% (HPLC), estrogen receptor β agonist, powder
Sinónimos:
DPN, Diarylpropionitrile, SC-4473
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C15H13NO2
Número CAS:
Peso molecular:
239.27
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Permítanos ayudarleNombre del producto
2,3-Bis(4-hydroxyphenyl)propionitrile, ≥98% (HPLC)
SMILES string
Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1
InChI key
GHZHWDWADLAOIQ-UHFFFAOYSA-N
InChI
1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
sterility
non-sterile
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 10 mg/mL, clear
shipped in
ambient
storage temp.
−20°C
Quality Level
Categorías relacionadas
Biochem/physiol Actions
2,3-Bis(4-hydroxyphenyl)-propionitrile (Diarylprepionitrile, DPN) is an ERβ-selective agonist; IC50 = 15nM. DPN protects WT and ARKO mice and significantly decreases IL-1β following LPS treatment in young adult-derived microglia. PPT (Cat. No.H6036, ERa agonist) enhances cell proliferation, while DPN inhibits it. PPT increases Bcl-2 expression, while DPN decreases it. DPN also elevates Bax expression. DPN induces a dose-dependent increase on vitellogenin synthesis. PPT and DPN are effective in dynamically, but differentially regulating intracellular calcium signaling in hippocampal neurons. DPN is more efficacious than PPT in potentiating a physiological concentration of glutamate-induced intracellular Ca2+ rise in these neurons. DPN prevents the development of prostatic hyperplasia and inflammation in testosterone-treated LuRKO mice.
2,3-Bis(4-hydroxyphenyl)-propionitrile is an ERβ-selective agonist; IC50 = 15nM.
Features and Benefits
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Eye Irrit. 2
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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