N193
1-Naphthylacetyl spermine trihydrochloride
≥95% (HPLC), Ca2+ permeable AMPA receptor channel blocker, powder
Sinónimos:
NASPM trihydrochloride
Iniciar sesión para ver los precios por organización y contrato.
Seleccione un Tamaño
Cambiar Vistas
Acerca de este artículo
Fórmula empírica (notación de Hill):
C22H34N4O · 3HCl
Número CAS:
Peso molecular:
479.91
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
Storage condition:
desiccated, protect from light
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarleNombre del producto
1-Naphthylacetyl spermine trihydrochloride,
assay
≥95% (HPLC)
Quality Level
form
powder
storage condition
desiccated, protect from light
color
white
solubility
H2O: ≥20 mg/mL
SMILES string
Cl.Cl.Cl.NCCCNCCCCNCCCNC(=O)Cc1cccc2ccccc12
InChI
1S/C22H34N4O.3ClH/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20;;;/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27);3*1H
InChI key
JNEOJAUJWOPWJS-UHFFFAOYSA-N
Application
1-Naphthylacetyl spermine trihydrochloride has been used for the inhibition of calcium-permeable AMPAR (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor). It has also been used to study the involvement of AMPAR in biphasic activation of stress-activated protein kinase/extracellular signal-regulated kinase-1.
Biochem/physiol Actions
Blocks Ca2+ permeable AMPA receptor channels.
Other Notes
Synthetic analog of Joro spider toxin.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Elija entre una de las versiones más recientes:
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
K Oguro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(21), 9218-9227 (1999-10-26)
Considerable evidence suggests that Ca(2+)-permeable AMPA receptors are critical mediators of the delayed, selective neuronal death associated with transient global ischemia and sustained seizures. Global ischemia suppresses mRNA and protein expression of the glutamate receptor subunit GluR2 and increases AMPA
Cornelia Strobel et al.
The Journal of physiology, 595(16), 5653-5669 (2017-06-09)
Dendritic and spine calcium imaging in combination with electrophysiology in acute slices revealed that in medial intercalated cells of the amygdala: Action potentials back-propagate into the dendritic tree, but due to the presence of voltage-dependent potassium channels, probably Kv4.2 channels
Drosophila motor neuron boutons remodel through membrane blebbing coupled with muscle contraction.
Fernandes, et al.
Nature Communications, 14, 3352-3352 (2023)