N3136
Naltrexone hydrochloride
≥99% (HPLC), powder, opioid receptor antagonist
Sinónimos:
Naltrexone HCl
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Fórmula empírica (notación de Hill):
C20H23NO4 · HCl
Número CAS:
Peso molecular:
377.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
240-723-0
MDL number:
Beilstein/REAXYS Number:
3580333
Form:
powder
Quality level:
Servicio técnico
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Permítanos ayudarleNombre del producto
Naltrexone hydrochloride,
form
powder
Quality Level
originator
Novartis
storage temp.
2-8°C
SMILES string
Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6
InChI
1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
InChI key
RHBRMCOKKKZVRY-ITLPAZOVSA-N
Gene Information
human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)
Application
Naltrexone hydrochloride has been used:
- as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
- to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
- in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22
Biochem/physiol Actions
Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.
Features and Benefits
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Raquel Moreno-Vicente et al.
Journal of pharmaceutical and biomedical analysis, 114, 105-112 (2015-06-04)
A bioanalytical method using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated for simultaneous quantification of heroin, its main metabolites and naloxone. In addition, naltrexone was detected qualitatively. This method was used to analyse human plasma samples from
Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A)
Prukop T, et al.
Testing, 14(1), e0209752-e0209752 (2019)
Caenorhabditis elegans show preference for stimulants and potential as a model organism for medications screening
Engleman EA, et al.
Frontiers in Physiology, 9, 7-16 (2018)