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Merck

P4638

Poly-L-ornithine hydrobromide

Mol wt >100,000

Sinónimos:

L-Ornithine homopolymer hydrobromide

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Número CAS:
UNSPSC Code:
12352209
NACRES:
NA.26
MDL number:
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Nombre del producto

Poly-L-ornithine hydrobromide, mol wt >100,000

SMILES string

[Br-].NC(CCCN)C(=O)O.[H+]

InChI

1S/C5H12N2O2.BrH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H

InChI key

GWRQMKDBBHFVIZ-UHFFFAOYSA-N

form

powder

mol wt

>100,000

color

white to off-white

storage temp.

−20°C

Quality Level

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Analysis Note

Molecular weight based on viscosity.

Application


  • Thermodynamic Characterization of Polypeptide Complex Coacervation.: The research investigates the thermodynamic properties of polypeptide complex coacervation, including the role of Poly-L-ornithine hydrobromide in these interactions. This study provides insights into the self-assembly processes of polypeptides, which are crucial for designing new biomaterials (Priftis et al., 2012).

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Omaditya Khanna et al.
Journal of biomedical materials research. Part A, 95(2), 632-640 (2010-08-21)
Alginate microcapsules coated with a permselective poly-L-ornithine (PLO) membrane have been investigated for the encapsulation and transplantation of islets as a treatment for type 1 diabetes. The therapeutic potential of this approach could be improved through local stimulation of microvascular
E Ramsay et al.
Journal of drug targeting, 10(1), 1-9 (2002-05-09)
Gene transfer vectors formed between the cationic polyamino acid, poly-(L)-omithine (PLO) and plasmid DNA (pDNA) have demonstrated superior transfection efficiency (up to x 10-fold) compared to equivalent polylysine-based systems in-vitro. The mechanism(s) underlying this observation remains to be elucidated. We
Ana Borrajo et al.
Neuropharmacology, 85, 1-8 (2014-06-01)
Several recent studies have shown that activation of the RhoA/Rho-associated kinase (ROCK) pathway is involved in the MPTP-induced dopaminergic cell degeneration and possibly in Parkinson's disease. ROCK inhibitors have been suggested as candidate neuroprotective drugs for Parkinson's disease. However, the
A R Boccaccini et al.
Journal of the Royal Society, Interface, 7 Suppl 5, S581-S613 (2010-05-28)
Electrophoretic deposition (EPD) is attracting increasing attention as an effective technique for the processing of biomaterials, specifically bioactive coatings and biomedical nanostructures. The well-known advantages of EPD for the production of a wide range of microstructures and nanostructures as well
S K Tam et al.
Acta biomaterialia, 7(4), 1683-1692 (2010-12-15)
There is a need for better understanding of the biocompatibility of alginate-polycation microcapsules based on their physicochemical characteristics. Microcapsules composed of alginate with 44% (IntG) or 71% (HiG) guluronate, gelled with calcium (Ca) or barium (Ba) and coated with poly-L-lysine

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