P9255
Pyridoxal 5′-phosphate hydrate
≥98%
Sinónimos:
Pyridoxal phosphate, 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde, Codecarboxylase, PLP, Pyridoxal 5-phosphate
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Fórmula empírica (notación de Hill):
C8H10NO6P · xH2O
Número CAS:
Peso molecular:
247.14 (anhydrous basis)
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
EC Number:
200-208-3
Beilstein/REAXYS Number:
234749
MDL number:
Servicio técnico
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Permítanos ayudarlebiological source
synthetic (organic)
Quality Segment
assay
≥98%
form
powder
technique(s)
HPLC: suitable
color
beige, off-white to yellow
mp
140-143 °C
storage temp.
−20°C
SMILES string
CC1=NC=C(COP(O)(O)=O)C(C([H])=O)=C1O
InChI
1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChI key
NGVDGCNFYWLIFO-UHFFFAOYSA-N
General description
Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway. It is the active form of pyridoxine.
Application
Pyridoxal 5′-phosphate hydrate has also been used:
- as a reference standard to quantify vitamin B6 in feed and digesta samples using high performance liquid chromatography (HPLC)
- in D-amino acid transaminase reaction(10)
- as a cofactor for L-glutamic acid decarboxylase
Biochem/physiol Actions
Pyridoxal 5′-phosphate (PLP) aids in carbohydrate and fat metabolism by serving as a cofactor. It is majorly responsible for catalyzing the enzymatic reactions involved in sphingolipid synthesis and neurotransmitter (dopamine and serotonin) synthesis. PLP is used in the studies of PLP-dependent enzyme active sites. PLP is also a cofactor for a wide range of enzymes including mitochondrial 5-Aminolevulinic acid synthase (ALAS) cysteine desulfurase, cystathionine γ-synthase (CGS), ornithine 4,5-aminomutase (OAM), and D-serine dehydratase.
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Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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