P9273
Pro-Phe-Arg-7-amido-4-methylcoumarin
≥95%
Sinónimos:
PFR-Nmec
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Fórmula empírica (notación de Hill):
C30H37N7O5 · C2H4O2
Número CAS:
Peso molecular:
635.71
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
Servicio técnico
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Permítanos ayudarleQuality Level
assay
≥95%
form
powder
composition
Peptide content, ≥65%
solubility
methanol: 50 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
SMILES string
NC(NCCC[C@@H](C(NC1=CC=C(C(C)=CC(O2)=O)C2=C1)=O)NC([C@H](CC3=CC=CC=C3)NC(C4NCCC4)=O)=O)=N.CC([O-])=O
InChI
1S/C30H37N7O5.ClH/c1-18-15-26(38)42-25-17-20(11-12-21(18)25)35-28(40)23(10-6-14-34-30(31)32)36-29(41)24(16-19-7-3-2-4-8-19)37-27(39)22-9-5-13-33-22;/h2-4,7-8,11-12,15,17,22-24,33H,5-6,9-10,13-14,16H2,1H3,(H,35,40)(H,36,41)(H,37,39)(H4,31,32,34);1H
InChI key
QYFPUTDFLKFOBA-UHFFFAOYSA-N
General description
A fluorogenic substrate for pancreatic and urinary kallikreins.
Application
Pro-Phe-Arg-7-amido-4-methylcoumarin has been used as fluorogenic substrate:
- in kinetic experiments to measure the enzymatic activity of factor XII
- to measure the activity of generated plasma kallikrein using Spectramax plate reader
- to determine the cathepsin A (CatA) inhibitor selectivity against various proteases using Tecan Safire 2 plate reader
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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S Paul et al.
Journal of immunology (Baltimore, Md. : 1950), 159(3), 1530-1536 (1997-08-01)
Polyreactive and thyroglobulin (Tg)-directed proteolytic activities present in the serum IgG of healthy controls and patients with autoimmune disease were studied by electrophoretic separation of 125I-labeled Tg reaction products and spectrofluorometric measurement of Pro-Phe-Arg-methylcoumarinamide cleavage at the Arg-methylcoumarinamide bond. A
K Uchida et al.
Biochimica et biophysica acta, 614(2), 501-510 (1980-08-07)
Kallikrein (EC 3.4.21.8) was purified from rat stomach by column chromatography on p-aminobenzamidine-Sepharose, DEAE-Sephadex A-50 and Sephadex G-150 and by isoelectric focusing, measuring its activities to hydrolyse L-prolyl-L-phenylalanyl-L-arginine-4-methyl-coumaryl-7-amide and to release kinin from heat-treated rat plasma. the purified stomach kallikrein
Sven Ruf et al.
Journal of medicinal chemistry, 55(17), 7636-7649 (2012-08-07)
Cathepsin A (CatA) is a serine carboxypeptidase distributed between lysosomes, cell membrane, and extracellular space. Several peptide hormones including bradykinin and angiotensin I have been described as substrates. Therefore, the inhibition of CatA has the potential for beneficial effects in