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Merck

P9767

Sodium palmitate

≥98.5%

Sinónimos:

Hexadecanoic acid sodium salt, Palmitic acid sodium salt

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About This Item

Fórmula lineal:
CH3(CH2)14COONa
Número CAS:
408-35-5
Peso molecular:
278.41
UNSPSC Code:
12352211
NACRES:
NA.25
PubChem Substance ID:
24899061
EC Number:
206-988-1
Beilstein/REAXYS Number:
3575882
MDL number:
MFCD00002749

Nombre del producto

Sodium palmitate, ≥98.5%

InChI

1S/C16H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;/h2-15H2,1H3,(H,17,18);/q;+1/p-1

InChI key

GGXKEBACDBNFAF-UHFFFAOYSA-M

SMILES string

[Na+].CCCCCCCCCCCCCCCC([O-])=O

biological source

plant (palm)

assay

≥98.5%

form

powder

mp

283-290 °C (lit.)

functional group

ester

lipid type

saturated FAs

shipped in

ambient

storage temp.

2-8°C

Quality Level

200

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Application

Sodium palmitate (PA) has been used:
  • to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay
  • to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis
  • as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining

Biochem/physiol Actions

Sodium palmitate is the sodium salt of palmitic acid, a component in hard soaps. Palmitic acid is a common saturated fatty acid and produced during fatty acid synthesis. Sodium palmitate enhances lipogenesis, cellular steatosis in various cell lines. Palmitate induces cell death in human epidermal growth factor receptor 2 (HER2)/neu-positive cells and breast cancer cell lines like MCF-7 due to enhanced fatty acid accumulation. Sodium palmitate induces lipoapoptosis in L02 and HepG2 liver cells by inducing glycogen synthase kinase-3β (GSK3β) expression.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000494014
0000494001
0000494001
0000494014
0000493064

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I dissolve Sodium palmitate, Product P9767?

    We test the solubility in methanol at 50 mg/mL.

  4. How do I dissolve Sodium palmitate, Product P9767?

    Sodium palmitate does not dissolve readily in methanol at room temperature.  We test the solubility by heating it for up to 15 minutes to get a clear, colorless solution. Note that the boiling point of methanol is approximately 65°C.

  5. How do I store Sodium palmitate, Product P9767, as provided?

    This compound is stable for years at 2-8°C.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro
Park MJ, et al.
Cellular Signalling, 27(9), 1831-1839 (2015)
Kyong Kim et al.
Nutrients, 11(7) (2019-07-07)
Allomyrina dichotoma larva is a nutritional-worthy future food resource and it contributes to multiple pharmacological functions. However, its antidiabetic effect and molecular mechanisms are not yet fully understood. Therefore, we investigated the hypolipidemic effect of A. dichotoma larva extract (ADLE)
Saturated fatty acid palmitate induces extracellular release of histone H3: a possible mechanistic basis for high-fat diet-induced inflammation and thrombosis
Shrestha C, et al.
Biochemical and Biophysical Research Communications, 437(4), 573-578 (2013)
José M S Fernández-Calleja et al.
Scientific reports, 9(1), 11507-11507 (2019-08-10)
Indirect calorimetry (InCa) estimates whole-body energy expenditure and total substrate oxidation based on O2 consumption and CO2 production, but does not allow for the quantification of oxidation of exogenous substrates with time. To achieve this, we incorporated 13CO2 and 12CO2
Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3 beta activation in human liver cells
Cao J, et al.
Digestive Diseases and Sciences, 59(2), 346-357 (2014)
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