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Merck

R4528

Anti-hnRNP-A1 antibody, Mouse monoclonal

clone 9H10, purified from hybridoma cell culture

Sinónimos:

Anti-heterogeneous nuclear ribonucleoprotein-A1

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UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD06798702

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Nombre del producto

Anti-hnRNP-A1 antibody, Mouse monoclonal, clone 9H10, purified from hybridoma cell culture

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

9H10, monoclonal

form

buffered aqueous solution

mol wt

antigen ~34 kDa

species reactivity

human, hamster, monkey, rat, bovine, mouse, canine

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 0.5-1.0 μg/mL using total cell extract of 293T cells

isotype

IgG2b

UniProt accession no.

P09651

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... HNRNPA1(3178)
mouse ... Hnrnpa1(15382)
rat ... Hnrnpa1(29578)

Application

Anti-hnRNP-A1 has been used in immunofluorescence, immunohistochemistry and western blotting.

Does not immunoprecipitate the hnRNP complex.

Biochem/physiol Actions

hnRNP-A1 (heterogeneous nuclear ribonucleoprotein) participates in several RNA metabolisms. It also participates in deep vein thrombosis patients with behçet′s disease. hnRNPA1 mutations results in amyotrophic lateral sclerosis and multisystem proteinopathy.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

hnRNP-A1 (heterogeneous nuclear ribonucleoprotein) is a pre-mRNA/mRNA binding protein, that belongs to the hnRNP family. It is located in chromosome 12q13.1. It is located in the nucleoplasm but it travels between the nucleus and the cytoplasm. It has two RNP motif RNA-binding domains (RBDs) at the amino terminus and a glycine-rich domain at the carboxyl terminus.

Immunogen

purified human hnRNP-A1.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

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Clase de almacenamiento

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000197161
0000184114
0000184114
0000197161
049M4774V

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Carolina Villarroya-Beltri et al.
Nature communications, 4, 2980-2980 (2013-12-21)
Exosomes are released by most cells to the extracellular environment and are involved in cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs (miRNAs) and other non-coding RNAs that can be functionally transferred to recipient cells. However, the mechanisms that
HnRNP A1 is Involved in Deep Vein Thrombosis Patients with Behcet's Disease
Chen P, et al.
EBioMedicine, 6, 215-221 (2016)
Profiling murine tau with 0N, 1N and 2N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus
Liu C and Gotz J
PLoS ONE, 8(12) (2013)
A nuclear localization domain in the hnRNP A1 protein
Siomi H and Dreyfuss G
The Journal of Cell Biology, 129(3), 551-560 (1995)
Simon Braun et al.
Nature communications, 9(1), 3315-3315 (2018-08-19)
Mutations causing aberrant splicing are frequently implicated in human diseases including cancer. Here, we establish a high-throughput screen of randomly mutated minigenes to decode the cis-regulatory landscape that determines alternative splicing of exon 11 in the proto-oncogene MST1R (RON). Mathematical
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