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Merck

S0278

(±)-Sotalol hydrochloride

≥98% (TLC), powder, β-Adrenoceptor antagonist

Sinónimos:

N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride

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Fórmula empírica (notación de Hill):
C12H20N2O3S · HCl
Número CAS:
959-24-0
Peso molecular:
308.82
NACRES:
NA.77
PubChem Substance ID:
24278689
UNSPSC Code:
12352200
EC Number:
213-496-0
MDL number:
MFCD00242937

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Nombre del producto

(±)-Sotalol hydrochloride, ≥98% (TLC), powder

InChI key

VIDRYROWYFWGSY-UHFFFAOYSA-N

InChI

1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H

SMILES string

Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1

assay

≥98% (TLC)

form

powder

color

white to off-white

solubility

H2O: 20 mg/mL

originator

Bayer

Quality Level

200

Gene Information

human ... ADRB1(153), ADRB2(154), ADRB3(155), KCNH2(3757)

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Application

(±)-Sotalol hydrochloride has been used to test its effect on the cardiac action potential (AP) in human hearts. It has also been used as an β- blocker to determine its effect on free intracellular calcium (Ca2+) release and whole-cell currents in mammalian cancer cells.

Biochem/physiol Actions

Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.
Sotalol has a potential to block non-cardioselective β-adrenergic receptors. It acts as an anti-arrhythmic agent and is used as a therapeutic for equine arrhythmias. In addition, sotalol also has an ability to stop atrial fibrillation recurrence.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000453979
0000453979
0000442218
0000442218
0000404418

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Visite la Librería de documentos

Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines
Reyes-Corral M, et al.
Journal of Pharmacology and Experimental Therapeutics, 369(1), 152-162 (2019)
J S Pasnani et al.
The Journal of pharmacology and experimental therapeutics, 271(1), 184-192 (1994-10-01)
Pro- and antiarrhythmic effects of dl-sotalol and d-sotalol were compared with their electrophysiological actions in an isolated tissue model of simulated ischemia and reperfusion. Microelectrode recordings were made from endo- and epicardium of isolated guinea pig right ventricular free walls.
W J Groh et al.
Circulation, 91(2), 262-264 (1995-01-15)
Catecholamines antagonize the efficacy of several class III antiarrhythmic agents. To determine the role of the intrinsic beta-adrenergic blocking property of dl-sotalol in maintaining class III efficacy during a high-catecholamine state, we compared the electrophysiological properties of dl-sotalol with those
Pharmacokinetics of intravenously and orally administered sotalol hydrochloride in horses and effects on surface electrocardiogram and left ventricular systolic function
Broux B, et al.
The Veterinary Journal, 208, 60-64 (2016)
[QTc-prolongation in acute drug-poisoning. Guidelines for management from the Swedish Poisons Information Centre].
Jonas Höjer
Lakartidningen, 110(19-20), 953-955 (2013-06-12)
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