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Merck

S6635

Span® 20

greener alternative

Sinónimos:

Sorbitan laurate, Sorbitan monolaurate

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Número CAS:
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12161900
EC Number:
215-663-3
MDL number:
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description

non-ionic

Quality Level

mol wt

346.47 g/mol

greener alternative product characteristics

Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

concentration

≥44% (GC)

greener alternative category

SMILES string

CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O

InChI

1S/C18H34O6/c1-2-3-4-5-6-7-8-9-10-11-16(21)23-13-15(20)18-17(22)14(19)12-24-18/h14-15,17-20,22H,2-13H2,1H3/t14-,15?,17+,18+/m0/s1

InChI key

LWZFANDGMFTDAV-WYDSMHRWSA-N

General description

Span 20 is a co-surfactant.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is 100% bio-based non-ionic surfactant, thus aligns with "Use of Renewable Feedstocks" and belongs to "12 principles aligned" category of our greener alternatives.

Application

Span 20 has been used in a study to assess enhanced solubility and oral bioavailability of itraconazole. It has also been used in a study to investigate the oxidation of unsaturated lipids in oil-in-water emulsions.

Other Notes

Fatty acid composition: Lauric acid (C12:0) ≥ 44%; balance primarily myristic (C14:0), palmitic (C16:0) and linolenic (C18:3) acids.

Legal Information

Span is a registered trademark of Croda International PLC


Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 1

flash_point_f

>300.2 °F - closed cup

flash_point_c

> 149 °C - closed cup

ppe

Eyeshields, Gloves, type N95 (US)



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Claire Berton et al.
Journal of colloid and interface science, 377(1), 244-250 (2012-04-25)
The development of lipid oxidation in oil-in-water (O/W) emulsions is widely influenced by the properties of the interfacial layer, which separates the oil and water phases. In this work, the effect of the structure of the interface on the oxidative
Muhammad Moniruzzaman et al.
Journal of colloid and interface science, 352(1), 136-142 (2010-09-10)
In this paper, we report a novel ionic liquid-in-oil (IL/o) microemulsion which is able to dissolve pharmaceuticals that are insoluble or sparingly soluble in water and most of pharmaceutical grade organic liquids. Towards this approach, the nanometer-sized ionic liquid droplets
Muhammad Moniruzzaman et al.
International journal of pharmaceutics, 400(1-2), 243-250 (2010-09-04)
Pharmaceutical industries have posed challenges in the topical and transdermal administration of drugs which are poorly soluble or insoluble in water and most of organic solvents. In an approach to overcome this limitation, ionic liquid-in-oil (IL/o) microemulsions (MEs) were employed