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Merck

SAB4200272

Anti-Progerin antibody, Mouse monoclonal

clone 13A4, purified from hybridoma cell culture

Sinónimos:

Anti-CDCD1, Anti-CDDC, Anti-CMD1A, Anti-CMT2B1, Anti-EMD2, Anti-FPL, Anti-FPLD, Anti-HGPS, Anti-IDC, Anti-LDP1, Anti-LFP, Anti-LMN1, Anti-LMNA, Anti-LMNC, Anti-LMNL1, Anti-Lamin A/C, Anti-PRO1, Anti-Renal carcinoma antigen NY-REN-32

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Acerca de este artículo

NACRES:
NA.41
UNSPSC Code:
12352203

Documentos clave

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Nombre del producto

Anti-Progerin antibody, Mouse monoclonal, clone 13A4, purified from hybridoma cell culture

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

13A4, monoclonal

form

buffered aqueous solution

mol wt

antigen ~70 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): suitable
indirect immunofluorescence: suitable
western blot: 2.5-5.0 μg/mL using whole extracts of HeLa cells overexpressing human progerin.

isotype

IgG1

UniProt accession no.

P02545

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LMNA(4000)

Application

Monoclonal Anti-Progerin antibody produced in mouse has been used in:
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

Biochem/physiol Actions

Mutations in Lamin A have been linked to a variety of rare human diseases including muscular dystrophy, lipodystrophy, cardiomyopathy, neuropathy and progeroid syndromes (collectively termed laminopathies) and to premature aging (Hutchinson-Gilford progeria syndrome). Lamins A/C participate in maintaining nuclear integrity, modulation of gene expression, cell proliferation and apoptosis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Monoclonal Anti-Progerin (mouse IgG1 isotype) is derived from the hybridoma 13A4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. A-type lamins, lamin A and lamin C are products of a single gene, LMNA, which are produced by alternative splicing. Prelamin A, the precursor of Lamin A, is farnesylated at its carboxy terminus after synthesis and the last 18 amino acids, which contain the farnesyl group, are removed by the metalloprotease Zmpste24, producing the mature Lamin A. The LMNA gene codes for A-type lamin, lamin A/C.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Clase de almacenamiento

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000517283
0000517283
0000490144
0000490144
0000458284

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Expression of Lamin A/C in early-stage breast cancer and its prognostic value
Alhudiri IM, et al.
Breast Cancer Research and Treatment, 174(3), 661-668 (2019)
Hippocampal LMNA Gene Expression is Increased in Late-Stage Alzheimer?s Disease
Lopez IM, et al.
International Journal of Molecular Sciences, 20(4) (2019)
Nuria Coll-Bonfill et al.
Proteomics, 20(5-6), e1800406-e1800406 (2019-12-14)
Hutchinson Gilford progeria syndrome (HGPS) is a devastating accelerated aging disease caused by LMNA gene mutation. The truncated lamin A protein produced "progerin" has a dominant toxic effect in cells, causing disruption of nuclear architecture and chromatin structure, genomic instability
Wei Jin et al.
Cell & bioscience, 12(1), 31-31 (2022-03-17)
Mesenchymal stem cells (MSCs) are emerging as the mainstay of regenerative medicine because of their ability to differentiate into multiple cell lineages. The infinite proliferative potential of human pluripotent stem cells (PSCs) grants an unlimited supply of MSCs. Despite their

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