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Merck

SAE0073

Saponin

Sinónimos:

Surfactant Saponin

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UNSPSC Code:
12161902
EC Number:
232-462-6
NACRES:
NA.21
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description

non-ionic

Quality Level

composition

Sapogenin content, 20-35%

technique(s)

HPLC: suitable, LC/MS: suitable, protein quantification: suitable

sulfated ash

≤10%

Application

Saponins has been used to permeabilize dendritic cells (DCs) for intracellular staining with antibodies.

Biochem/physiol Actions

Saponins are associated with many biological and pharmacological activities. It is known to stimulate immune response in mammals. Saponins possesses antiviral, antifungal, antitumor, anti-inflammatory, hypoglycemic and hypocholesterolemic effects. It is a potent hemolytic, when injected intravaneously. It is also useful as a surfactant to enhance penetration of proteins and other macromolecules through cell membranes. Saponins have also been used as adjuvants for vaccines.

Packaging

10, 25 g in poly bottle


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable



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Flavia Radogna et al.
Methods in molecular biology (Clifton, N.J.), 2276, 129-141 (2021-06-02)
Cellular energy metabolism is regulated by complex metabolic pathways. Although anaerobic glycolysis was reported as a primary source of energy in cancer leading to a high rate of lactate production, current evidence shows that the main energy source supporting cancer
Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation
Gotoh K, et al.
Cell Reports, 25(7), 1800-1815 (2018)
Sónia A Pinho et al.
The FEBS journal, 289(17), 5198-5217 (2022-02-26)
Cell culture conditions highly influence cell metabolism in vitro. This is relevant for preclinical assays, for which fibroblasts are an interesting cell model, with applications in regenerative medicine, diagnostics and therapeutic development for personalized medicine, and the validation of ingredients for