SRP3018
Beta -NGF human
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Sinónimos:
beta-Nerve Growth Factor
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NACRES:
NA.32
UNSPSC Code:
12352202
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Permítanos ayudarlebiological source
human
recombinant
expressed in E. coli
assay
≥98% (HPLC), ≥98% (SDS-PAGE)
form
lyophilized
potency
<1.0 ng/mL ED50
mol wt
13.5 kDa
packaging
pkg of 20 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... NFG(4803)
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General description
NGFβ (nerve growth factor β) is a protein involved in signal transduction, and expressed by multiple tissues such as placenta, urothelium and bladder smooth muscle cells. It was discovered by Levi-Montalcini, and is the founding member of the neurotrophin and belongs to the NGF family.
Application
NGFβ (nerve growth factor β) has been used for the treatment of normal human bronchial epithelial cells (NHBE), to determine its influence on ion transport in the presence of amiloride, NPPB, and ouabain. It has also been used for the apical incubation with MKHS (modified Krebs-Henseleit solution) in cells to determine its stability and concentration post- prolonged incubation periods in MKHS.
Biochem/physiol Actions
NGFβ (nerve growth factor β) is essential for the differentiation and survival of neurons. It also plays a key role in the development and maintenance of nervous system. It is also involved in angiogenesis, and facilitates tumorigenesis such as, oral, breast and prostate cancers. It has potential as marker for the diagnosis of interstitial cystitis/painful bladder syndrome (IC/PBS) and overactive bladder (OAB), and might also aid in determining the therapy for the same. It might be involved in changes in placental function, as NGFβ signaling is influenced by antenatal depression and selective serotonin reuptake inhibitor (SSRI) treatment.
Physical form
Lyophilized with no additives.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a Stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.
Other Notes
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVR
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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