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T2265

Tetraethylammonium chloride

Name: Tetraethylammonium chloride
Brand: SIGMA

synthetic (organic), ≥98% (titration), K+ channels blocker, powder

Sinónimos:

TEA chloride

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Fórmula lineal:

(C₂H₅)₄N(Cl)

Número CAS:

56-34-8

Peso molecular:

165.70

NACRES:

NA.32

PubChem Substance ID:

24277874

UNSPSC Code:

12352107

EC Number:

200-267-5

MDL number:

MFCD00011828

Beilstein/REAXYS Number:

3563247

Form:

powder

Assay:

≥98% (titration)

Biological source:

synthetic (organic)

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Propiedades

Nombre del producto

Tetraethylammonium chloride, ≥98% (titration)

biological source

synthetic (organic)

assay

≥98% (titration)

form

powder

technique(s)

blocking: suitable

color

white to light yellow

SMILES string

[Cl-].CC[N+](CC)(CC)CC

InChI

1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1

InChI key

YMBCJWGVCUEGHA-UHFFFAOYSA-M

Gene Information

human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)

Descripción

Application

Tetraethylammonium chloride (TEAC) has been used:

used for inhibition of peroxynitrite induced relaxation in rat aorta rings
as a pharmacological blocker of K⁺ current and Ca²⁺ induced K⁺ current in antennal lobe neurons
for the induction of TEAC sensitive currents in cochlear inner hair cells digested with proteolytic enzymes and analyze its properties

Biochem/physiol Actions

Blocks K⁺ channels; blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K⁺ currents.

Tetraethylammonium chloride (TEAC) blocks K⁺ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K⁺ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).