T5516

3,3′,5-Triiodo-L-thyronine sodium salt

Name: 3,3′,5-Triiodo-<SC>L</SC>-thyronine sodium salt
Brand: SIGMA

γ-irradiated, powder, suitable for, suitable for cell culture

Sinónimos:

Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T₃

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About This Item

Fórmula empírica (notación de Hill):

C₁₅H₁₁I₃NNaO₄

Número CAS:

55-06-1

Peso molecular:

672.96

UNSPSC Code:

12352207

NACRES:

NA.77

PubChem Substance ID:

24900290

EC Number:

200-223-5

Beilstein/REAXYS Number:

8179867

MDL number:

MFCD00002594

biological source:

synthetic (organic)

form:

powder

assay:

≥90% (HPLC)

Nombre del producto

3,3′,5-Triiodo-L-thyronine sodium salt, γ-irradiated, powder, suitable for, suitable for cell culture

InChI key

SBXXSUDPJJJJLC-YDALLXLXSA-M

InChI

1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1

SMILES string

[Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O

biological source

synthetic (organic)

sterility

γ-irradiated

assay

≥90% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

suitability

suitable for

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Gene Information

human ... THRA(7067), THRB(7068)
rat ... Thra(81812), Thrb(24831)

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Application

3,3′,5-Triiodo-L-thyronine sodium salt has been used:

as a supplement in colon organ culture media
to stimulate HuH-7 cells for analysing the hormonal influence on MBL synthesis
to study its effect on human growth hormone (GH) versus mouse GH expression in the presence of ′′intact′′ GH genes and in a common pituitary cell context

Biochem/physiol Actions

3,3′,5′-Triiodo-L-thyronine (T3) is a thyroid hormone that increases rates of proteins synthesis, stimulates the breakdown of cholesterol, and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.

General description

3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Preparation Note

Package size based on 3,3′,5-Triiodo-L-thyronine sodium salt content; vial may also contain inert salts, such as sodium chloride

To prepare 20 μg/ml stock solution: add 1 ml 1 N NaOH; gently swirl to dissolve; add 49 ml sterile medium.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

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Hormones Growth Factors & Oncogenes, 219-219 (1987)

Hormonal regulation of mannan-binding lectin synthesis in hepatocytes

Sorensen CM, et al.

Clinical and Experimental Immunology, 145(1), 173-182 (2006)

Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity.

Irene Antolino-Lobo et al.

Drug metabolism and disposition: the biological fate of chemicals, 38(7), 1105-1112 (2010-04-15)

Metabolism plays an important role in the toxic effects caused by 3,4-methylenedioxymethamphetamine (MDMA). Most research has focused on the involvement of CYP2D6 enzyme in MDMA bioactivation, and less is known about the contribution of other cytochrome P450 (P450) and phase

Handbook of Behavior, Food and Nutrition, 2109-2109 (2011)

Hormonal regulation of mannan-binding lectin synthesis in hepatocytes.

C M Sørensen et al.

Clinical and experimental immunology, 145(1), 173-182 (2006-06-24)

Activation of the complement system via the plasma protein mannan-binding lectin (MBL) provides a first line of defence against infections. The plasma level of MBL is, in part, determined genetically, but may also be influenced by different hormones in vivo.

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