U3003
Uridine
powder, BioReagent, suitable for cell culture
Sinónimos:
1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside
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Fórmula empírica (notación de Hill):
C9H12N2O6
Número CAS:
Peso molecular:
244.20
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
EC Number:
200-407-5
Beilstein/REAXYS Number:
754902
MDL number:
Assay:
≥99%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
H2O: 50 mg/mL
Servicio técnico
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Permítanos ayudarlebiological source
synthetic (organic)
Quality Level
product line
BioReagent
assay
≥99%
form
powder
technique(s)
cell culture | mammalian: suitable
mp
163-167 °C (lit.)
solubility
H2O: 50 mg/mL
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
InChI
1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
InChI key
DRTQHJPVMGBUCF-XVFCMESISA-N
Gene Information
mouse ... Uck1(22245)
General description
Uridine is a uracil nucleoside, specific for RNA sequence. Uridine is present in blood, seminal fluid and cerebrospinal fluid. Uridine is a substrate for nucleotide synthesis in living organisms by de- novo and salvage pathways.
Application
Uridine has been used:
- as an inhibitor of schwann cell proliferation in rat dorsal root ganglia (DRG) neurons culture
- as a medium supplement for epiblasts culture
- as a component of 5-fluoro-2′-deoxyuridine stock solution used for neuronal culture
Biochem/physiol Actions
Uridine monophosphate is essential for protein glycosylation, polysaccharide biosynthesis and lipid metabolism. Oral administration of uridine is suggested for anisopoikilocytosis and epileptic encephalopathy disorders. Uridine has numerous biological functions like, treating dry eye syndrome, regulating nervous system and favors reproduction. High levels of uridine induces insulin resistance.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Preparation of rat brain aggregate cultures for neuron and glia development studies
Koito H and Li J
Journal of Visualized Experiments, 22(31), 625-633 (2009)
Characterisation of bovine epiblast-derived outgrowth colonies
Oestrup E, et al.
Reproduction, Fertility, and Development, 22(4), 625-633 (2010)
CAD mutations and uridine-responsive epileptic encephalopathy
Koch J, et al.
Brain, 140(2), 279286-279286 (2016)