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Merck

1176007

USP

Dexametasona

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

(11β,16α)-9-Fluoro-11,17,21-trihidroxi-16-metilpregna-1,4-dieno-3,20-diona, 9α-Fluoro-16α-metil-11β,17α,21-trihidroxi-1,4-pregnadieno-3,20-diona, 9α-fluoro-16α-metilprednisolona, Prednisolona F

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About This Item

Fórmula empírica (notación de Hill):
C22H29FO5
Número CAS:
50-02-2
Peso molecular:
392.46
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329749548
MDL number:
MFCD00064136
Beilstein/REAXYS Number:
2066651

Nombre del producto

Dexametasona, United States Pharmacopeia (USP) Reference Standard

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

biological source

synthetic

grade

pharmaceutical primary standard

agency

USP

vapor pressure

<0.0000001 kPa ( 25 °C)

API family

dexamethasone

packaging

pkg of 125 mg

manufacturer/tradename

USP

color

white

mp

262-264 °C (lit.)

solubility

acetone: sparingly soluble
chloroform: slightly soluble
ethanol: sparingly soluble
ether: very slightly soluble
methanol: sparingly soluble
water: practically insoluble

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... NR3C1(2908)

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Categorías relacionadas

Biochem/physiol Actions

Glucocorticoide antiinflamatorio
Glucocorticoide antiinflamatorio. Regula la supervivencia, el crecimiento y la diferenciación de las células T. Inhibe la inducción de la óxido nítrico sintasa.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Dexamethasone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Ciprofloxacin and Dexamethasone Otic Suspension
  • Dexamethasone
  • Dexamethasone Compounded Oral Suspension
  • Dexamethasone Elixir
  • Dexamethasone Injection
  • Dexamethasone Ophthalmic Suspension
  • Dexamethasone Oral Solution

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Visite la Librería de documentos

Dexamethasone Oral Solution
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(6), 1288-1288 (2014)
Dexamethasone
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(4), 1284-1284 (2020)
Spectrophotometric resolution of ternary mixtures of Dexamethasone, Polymyxin B and Trimethoprim in synthetic and pharmaceutical formulations
Gallego JML and Arroyo JP
Analytica Chimica Acta, 437(2), 247-257 (2001)
Dexamethasone Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 45(6), 1289-1289 (2021)
Membrane stabilizing activity?a possible mechanism of action for the anti-inflammatory activity of Cedrus deodara wood oil
Shinde.AU, et al.
Fitoterapia, 70(3), 251-257 (1999)
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