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Merck

1463326

USP

Nicotine Related Compound A

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

Anatabine, (RS)-Anatabine, (±)-Anatabine, 1,2,3,6-Tetrahydro-2,3′-bipyridine, 1,2,3,6-Tetrahydro-2,3′-dipyridine

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Fórmula empírica (notación de Hill):
C10H12N2
Número CAS:
Peso molecular:
160.22
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
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grade

pharmaceutical primary standard

agency

USP

API family

nicotine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N1C(CC=CC1)c2cnccc2

InChI

1S/C10H12N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h1-4,6,8,10,12H,5,7H2

InChI key

SOPPBXUYQGUQHE-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Nicotine Related Compound A USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monograph such as:
  • Nicotine
  • Nicotine Polacrilex

Biochem/physiol Actions

Anatabine is a blood-brain barrier penetrant minor alkaloid, a cholinergic agonist, isolated from Solanaceae plant family that exhibits anti-inflammatory properties.
Anatabine is a blood-brain barrier penetrant minor alkaloid, a cholinergic agonist, isolated from Solanaceae plant family that exhibits anti-inflammatory properties. Apparently, anti-inflammatory properties of anatabine are partially mediated by inhibition of STAT3 and p65 NFkB phosphorylation. Anatabine decreases the transcription and protein synthesis of β-secretase (BACE-1), and appears to ameliorate experimental autoimmune thyroiditis and encephalomyelitis.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.


pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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