724459
Poly(N-isopropylacrylamide), carboxylic acid terminated
average Mn 10,000
Synonym(s):
NIPAM polymer, PNIPAM-COOH, Polyacrylamide, functionalized polyNIPAM, functionalized polyacrylamide, polyNIPAM
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About This Item
Linear Formula:
(C6H11NO)nSCH2CH2CO2H
NACRES:
NA.23
UNSPSC Code:
12162002
Quality Level
form
powder
mol wt
average Mn 10,000 by GPC (THF w/ 5%TEA, PS, RI), average Mn 10,000
mp
>300 °C
Application
Novel polymer for development of thermosensitive coated micro/nano materials including thermoresponsive polymeric drug delivery systems. The carboxylic acid functional group can be used to conjugate a variety of biomolecules to the polymer chain.
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
通过调整的理化特性，药物递送系统可根据需要设计为可递送治疗分子的智能系统。了解有关刺激响应材料药物递送应用的更多信息。
组织工程已成为治疗受损或患病的器官和组织（例如血管和尿囊）的关键治疗工具。
Biomaterials science integrates smart materials into biological research, requiring a deep understanding of biological systems.
Avraham Halperin et al.
Langmuir : the ACS journal of surfaces and colloids, 28(48), 16623-16637 (2012-11-06)
Thermoresponsive tissue culture substrates based on PNIPAM brushes are used to harvest confluent cell sheets for tissue engineering. The prospect of clinical use imposes the utilization of culture medium free of bovine serum, thus suggesting conjugation with adhesion peptides containing
Shahrzad Rayatpisheh et al.
Macromolecular bioscience, 12(7), 937-945 (2012-04-27)
A new method for ultrathin grafting of pNIPAm on PDMS surfaces is introduced that employs plasma activation of the surface followed by thermal polymerization. This method is optimized for human primary SMC attachment and subsequent intact cell sheet detachment by
Umut Atakan Gurkan et al.
Advanced healthcare materials, 1(5), 661-668 (2012-11-28)
Stimuli responsive, smart interface materials are integrated with microfluidic technologies creating new functions for a broad range of biological and clinical applications by controlling the material and cell interactions. Local capture and on-demand local release of cells are demonstrated with