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765112

Poly(L-lactide)

average Mn 10,000, PDI ≤1.1

Synonym(s):

PLA, PLLA, Polylactide, L-Lactide polymer, PLA, Poly(L-Lactic acid)

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About This Item

Linear Formula:
H(C3H4O2)nOCH3
NACRES:
NA.23
UNSPSC Code:
12162002
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form

solid

Quality Level

100

optical activity

[α]22/D -150°, c = 0.5% in chloroform

mol wt

average Mn 10,000

degradation timeframe

>3 years

transition temp

Tm 162-167 °C

PDI

≤1.1

storage temp.

2-8°C

General description

Poly (L-lactide) is a semi-crystalline polymer which exhibits strong optical rotation and good mechanical properties. It is mostly used in the synthesis of degradable polymers which are used in orthopaedic devices, in dental applications, as scaffolds for autografted new skin, wound covers, anastomose systems and stents. They are biodegradable since the polyester backbone degrades by simple hydrolysis to form non-toxic compounds.

Application

Drug Delivery including coating nanoparticles; end-group functionalization; macroinitiator or block precursor.

Features and Benefits

High initial strength, good strength retention and high amount of crystallinity, as much as 70%, which in turn is responsible for the very slow degradation rate.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX6744
MKCX2155
MKCN1975
MKCM5405
MKCG3203

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Electrospun Nanofibers for Drug Delivery Systems

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Biodegradable Polyester Nanoparticle Formation

AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.

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Synthesis and thermal properties of novel star-shaped poly (l-lactide)s with starburst PAMAM-OH dendrimer macroinitiator.
Zhao, Y. L., Cai, Q., Jiang, J., Shuai, X. T., Bei, J. Z., Chen, C. F., & Xi, F.
Polymer, 43(22), 5819-5825 (2002)
Chemical synthesis of polylactide and its copolymers for medical applications
Bendix, D.
Polymer Degradation and Stability, 59(1), 129-135 (1998)
Effect of poly (ethylene glycol)-block- poly (L-lactide) on the poly [(R)-3-hydroxybutyrate]/poly (L-lactide) blends
Yoon, J. S., Lee, W. S., Kim, K. S., Chin, I. J., Kim, M. N., & Kim, C.
Eur. Polymer J., 36(2), 435-442 (2000)
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