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Merck

A4403

L -抗坏血酸

powder, suitable for cell culture, γ-irradiated

别名:

维他命C, 抗坏血病因子, 维生素C

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关于此项目

经验公式(希尔记法):
C6H8O6
化学文摘社编号:
分子量:
176.12
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
EC Number:
200-066-2
Beilstein/REAXYS Number:
84272
MDL number:
Form:
powder
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biological source

synthetic (organic)

Quality Level

sterility

γ-irradiated

form

powder

mol wt

Mw 176.12 g/mol

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

color

white to off-white

pH

1.0-2.5 (25 °C, 176 g/L in water)

mp

190-194 °C (dec.)

solubility

H2O: 10 mg/mL

SMILES string

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

InChI key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

Gene Information

human ... SLC23A2(9962)

General description

L-抗坏血酸是一种不饱和γ-内酯环,含有与羰基相连的烯二醇构型(-COH =COH)。

Application

用于细胞培养,作为抗氧化剂和再生生育酚。
L-抗坏血酸已应用于:
  • 用于细胞生长的成骨补充剂
  • 作为分化介质的一个组成部分
  • 在WS-MSCs(沃纳综合征-间充质干细胞)中研究抗坏血酸对衰老缺陷的修复作用

Biochem/physiol Actions

L-抗坏血酸主要具有抗氧化性能。它保护植物免受氧化应激,保护哺乳动物免受与氧化应激相关的疾病。L-抗坏血酸主要对羟基自由基、超氧化物和单线态氧起保护作用。此外,它还还原膜连接的抗氧化剂α-生育酚(氧化形式)。L-抗坏血酸增强内皮依赖性血管舒张在各种疾病,包括糖尿病,冠状动脉疾病,高血压和慢性心力衰竭。


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存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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实验方案

产生人诱导多能干细胞(iPSC)的干细胞重编程实验方案,包括基于病毒和非病毒RNA的方法。

TrueGel3D® Hydrogel Plate protocol guides high-throughput culture of human adipose MSCs for screening applications.

Stem cell reprogramming protocols to generate human induced pluripotent stem cells (iPSCs) including viral and non-viral RNA based methods.

商品

Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.

Organoid culture products to generate tissue and stem cell derived 3D brain, intestinal, gut, lung and cancer tumor organoid models.

Importance and uses of ascorbate in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

查看所有文章

Plant L-ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing.
Davey MW
Journal of the Science of Food and Agriculture, 80, 825-860 (2000)
R Heller et al.
The Journal of biological chemistry, 274(12), 8254-8260 (1999-03-13)
Ascorbic acid has been shown to enhance impaired endothelium-dependent vasodilation in patients with atherosclerosis by a mechanism that is thought to involve protection of nitric oxide (NO) from inactivation by free oxygen radicals. The present study in human endothelial cells
P L Conklin et al.
Plant physiology, 115(3), 1277-1285 (1997-12-09)
The biosynthesis of L-ascorbic acid (vitamin C) is not well understood in plants. The ozone-sensitive Arabidopsis thaliana mutant vitamin c-1 (vtc1; formerly known as soz1) is deficient in ascorbic acid, accumulating approximately 30% of wild-type levels. This deficiency could result