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440025

Luteolin

Name: Luteolin
Brand: MM

≥90% (HPLC), antioxidant flavonoid, solid

Synonym(s):

Luteolin, 3ʹ,4ʹ,5,7-Tetrahydroxyflavone

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₀O₆

CAS Number:

491-70-3

Molecular Weight:

286.24

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00017309

Assay:

≥90% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

Product Name

Luteolin, An antioxidant flavonoid and a free radical scavenger.

Quality Segment

100

description

Merck USA index - 14, 5614

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

aqueous base: 1.4 mg/mL, DMSO: 7 mg/mL, ethanol: soluble

shipped in

ambient

storage temp.

2-8°C

SMILES string

[o]1c2c([c](cc1c3cc(c(cc3)O)O)=O)c(cc(c2)O)O

InChI

1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H

InChI key

IQPNAANSBPBGFQ-UHFFFAOYSA-N

Description

General description

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.

Biochem/physiol Actions

Cell permeable: no

Primary Target
rat liver cytosolic glutathione S-transferase activity

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.

Other Notes

Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther.in press.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol.38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med.16, 43.
Shimoi, L., et al. 1994. Carcinogenesis15, 2669.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c