459620
Okadaic Acid sodium salt
≥98% (TLC), solid,film (colorless), protein phosphatase 2A and protein phosphatase 1 inhibitor, Calbiochem®
Synonym(s):
Okadaic Acid, Sodium Salt
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About This Item
Empirical Formula (Hill Notation):
C44H67O13 · Na
Molecular Weight:
826.98
UNSPSC Code:
12352106
NACRES:
NA.77
Assay:
≥98% (TLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Product Name
Okadaic Acid, Sodium Salt, Water-soluble analog of Okadaic Acid. Inhibits protein phosphatases 1 and 2A.
Quality Level
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white to off-white
solubility
DMSO: 20 mg/mL, water: 1 mg/mL, ethanol: 20 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
Water-soluble analog of Okadaic Acid (Cat. No. 495604). Inhibits protein phosphatases 1 and 2A.
Biochem/physiol Actions
Cell permeable: no
Product does not compete with ATP.
Reversible: no
Target IC50: 10-15 nM, 0.1 nM against protein phosphatase 1, protein phosphatase 2A, respectively
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Gjertsen, B.T., et al. 1994. J. Cell Sci.107, 3363.
Kiguchi, K., et al. 1994. Cell Growth Differentiation5, 995.
Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun.197, 916.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun.189, 950.
Kreienbuhl, P., et al. 1992. Blood80, 2911.
Normura, M., et al. 1992. Biochemistry31, 11915.
Song, Q., et al. 1992. J. Cell Physiol.153, 550.
Tada, Y., et al. 1992. Immunopharmacol.24, 17.
Cohen, P., et al. 1990. Trends Biochem. Sci.15, 98.
Cohen, P. 1989. Annu. Rev. Biochem.58, 453.
Cohen, P., and Cohen, P.T.W. 1989. J. Biol. Chem.254 21435.
Haystead, T.A. et al. 1989. Nature337, 78.
Kiguchi, K., et al. 1994. Cell Growth Differentiation5, 995.
Ohaka, Y., et al. 1993. Biochem. Biophys. Res. Commun.197, 916.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun.189, 950.
Kreienbuhl, P., et al. 1992. Blood80, 2911.
Normura, M., et al. 1992. Biochemistry31, 11915.
Song, Q., et al. 1992. J. Cell Physiol.153, 550.
Tada, Y., et al. 1992. Immunopharmacol.24, 17.
Cohen, P., et al. 1990. Trends Biochem. Sci.15, 98.
Cohen, P. 1989. Annu. Rev. Biochem.58, 453.
Cohen, P., and Cohen, P.T.W. 1989. J. Biol. Chem.254 21435.
Haystead, T.A. et al. 1989. Nature337, 78.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Certificates of Analysis (COA)
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Protein phosphatases come of age.
P Cohen et al.
The Journal of biological chemistry, 264(36), 21435-21438 (1989-12-25)
Y Tada et al.
Immunopharmacology, 24(1), 17-24 (1992-07-01)
Okadaic acid is a potent tumor promoter and an inhibitor of serine/threonine-specific protein phosphatases. We studied the effect of okadaic acid in human T cell activation and phosphorylation of internal substrates. Okadaic acid at up to 4 nM enhanced phorbol
Q Song et al.
Journal of cellular physiology, 153(3), 550-556 (1992-12-01)
Gamma-radiation, tetrandrine, bistratene A, and cisplatin were all found to induce pronounced morphological changes characteristic of apoptosis and extensive DNA fragmentation in the human BM13674 cell line 8 h after treatment. Apoptosis induced in BM13674 cells by these diverse agents