Key Documents

View All Documentation

A1260

Amantadine hydrochloride

Name: Amantadine hydrochloride
Brand: SIGMA

≥98% (TLC), powder, NMDA receptor antagonist

Synonym(s):

1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride, NSC 83653, Tricyclo[3.3.1.1^3,7]decan-1-amine hydrochloride

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₇N · HCl

CAS Number:

665-66-7

Molecular Weight:

187.71

NACRES:

NA.77

PubChem Substance ID:

24277882

UNSPSC Code:

12352200

EC Number:

211-560-2

MDL number:

MFCD00074723

Beilstein/REAXYS Number:

4198854

Form:

powder

Quality level:

100

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Amantadine hydrochloride,

form

powder

Quality Level

100

solubility

H₂O: 50 mg/mL, ethanol: soluble

originator

Endo

SMILES string

Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3

InChI

1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;

InChI key

WOLHOYHSEKDWQH-SOVZANNPSA-N

Description

General description

Amantadine hydrochloride {tricyclo-[3,3,1,1]- deean-l-amine hydrochloride is a drug, which has rimantadine hydrochloride as its analog.

Application

Amantadine hydrochloride has been used:

to determine its effectiveness in reducing surgery-induced cognitive impairment
to preincubate multipotent stem cells (MSCs), to investigate the cellular internalization pathway
to determine whether amantadine-attenuated sepsis-induces neuroinflammation and dysfunction of learning and memory
to preincubate primary cultured rat dental pulp stem cells (rDPSCs)
to determine the pathway of internalization

Biochem/physiol Actions

Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.

Amantadine hydrochloride is effective against influenza viruses both in vivo and in vitro. It is considered as an antagonist of the N-methyl-D-aspartate (NMDA) type glutamate receptor. Amantadine plays an important role in the release of dopamine, preventing dopamine reuptake and blocking microglial activation and neuroinflammation.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Endo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Still not finding the right product?

Explore all of our products under Amantadine hydrochloride

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

pictograms

GHS08,GHS05,GHS07

signalword

Danger

hcodes

H302,H314,H361fd,H412

pcodes

P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Repr. 2 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000461265

0000439459

WXBF5496V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library