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Merck

A9512

L-(−)-Norepinephrine (+)-bitartrate salt monohydrate

≥99% (TLC), solid, vasoconstrictor

Synonym(s):

L-(−)-Noradrenaline (+)-bitartrate salt monohydrate

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About This Item

Empirical Formula (Hill Notation):
C8H11NO3 · C4H6O6 · H2O
CAS Number:
Molecular Weight:
337.28
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥99%
Form:
solid
Quality level:
Technical Service
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Product Name

L-(−)-Norepinephrine (+)-bitartrate salt monohydrate, ≥99%, solid

Quality Level

assay

≥99%

form

solid

color

white

solubility

H2O: 46 mg/mL

SMILES string

O.O[C@H]([C@@H](O)C(O)=O)C(O)=O.NC[C@H](O)c1ccc(O)c(O)c1

InChI

1S/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1

InChI key

LNBCGLZYLJMGKP-LUDZCAPTSA-N

Application

L-(-)-Norepinephrine (+)-bitartrate salt monohydrate has been used:
  • to infuse dogs to form a intracellular lipid accumulation model
  • to analyse the signaling involved in the up-regulation of monocarboxylate transporter 2 (MCT2) expression in cultured cortical neuron
  • in neurochemical preparation to study the response of gram-negative and gram-positive bacteria to norepinephrine
  • to study the roles of peripheral hormones on thyroid activity of turtles

Biochem/physiol Actions

Norepinephrine bitartrate plays an important role in in vivo and in vitro development of pathogenic and indigenous bacteria. It acts as a vasoconstrictor and adrenergic neurotransmitter.

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Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Oral

Storage Class

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges



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Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway
Chenal J and Pellerin L
Journal of Neurochemistry, 102(2), 389-397 (2007)
Roles of thyroid, adrenal and pancreatic hormones on thyroid activity of the soft-shelled turtles Lissemys punctata punctata Bonnoterre
Ray PP, et al.
Folia Biologica (Krakow.), 54(3-4), 93-102 (2006)
Gillian D Pullinger et al.
Veterinary research, 41(5), 68-68 (2010-07-09)
Salmonella enterica serovar Typhimurium is an animal and zoonotic pathogen of worldwide importance. In pigs, transport and social stress are associated with reactivation and spread of Salmonella Typhimurium infection. The stress-related catecholamine norepinephrine (NE) has been reported to activate growth