N6252
Norharmane
≥98% (TLC), crystalline, monoamine oxidase inhibitor
Synonym(s):
β-Carboline, 9H-Pyrido[3,4-b]indole
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About This Item
Empirical Formula (Hill Notation):
C11H8N2
CAS Number:
Molecular Weight:
168.19
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-959-0
MDL number:
Form:
crystalline
Quality level:
Product Name
Norharmane, crystalline
form
crystalline
Quality Level
color
light yellow
storage temp.
2-8°C
SMILES string
c1ccc2c(c1)[nH]c3cnccc23
InChI
1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
InChI key
AIFRHYZBTHREPW-UHFFFAOYSA-N
Gene Information
human ... IKBKB(3551)
rat ... Gabra2(29706)
General description
Norharmane is an alkaloid widely present in living organisms and can also be chemically synthesized. It is a β-carboline derivative composed of indole and pyridine.
Application
Norharmane has been used:
- as a β-carboline to study its effect on nigrostriatal dopamine (DA) neurons
- as an internal standard in gas chromatography-mass spectrometry (GC-MS) analyses using Conidiobulus coronatus filtrates
- as a β-carboline-3-carboxylic acid N-methylamide (CMA) analog to study its binding ability with Mcm2-7 (minichromosome maintenance)
Biochem/physiol Actions
Inhibitor of indoleamine 2,3-dioxygenase (IDO).
Norharmane and its derivative exhibit anti-cancer properties. It acts as a monoamine oxidase (MAO) inhibitor and might benefit Parkinson′s disease (PD). High levels of β-carboline in plasma are found in PD.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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