S9318
Sandoz 58-035
>98% (HPLC), powder, acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor
Synonym(s):
3-[Decyldimethylsilyl]-N-[2-(4-methylphenyl)-1-phenethyl]propanamide, SA 58-035
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About This Item
Empirical Formula (Hill Notation):
C30H47NOSi
CAS Number:
Molecular Weight:
465.79
UNSPSC Code:
41121801
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Sandoz 58-035, >98% (HPLC), powder
Quality Level
assay
>98% (HPLC)
form
powder
color
white
solubility
DMSO: 16 mg/mL, H2O: insoluble
originator
Novartis
storage temp.
2-8°C
SMILES string
CCCCCCCCCC[Si](C)(C)CCC(=O)NC(Cc1ccc(C)cc1)c2ccccc2
InChI
1S/C30H47NOSi/c1-5-6-7-8-9-10-11-15-23-33(3,4)24-22-30(32)31-29(28-16-13-12-14-17-28)25-27-20-18-26(2)19-21-27/h12-14,16-21,29H,5-11,15,22-25H2,1-4H3,(H,31,32)
InChI key
NBYATBIMYLFITE-UHFFFAOYSA-N
Gene Information
human ... SOAT1(6646)
rat ... Soat1(81782)
Application
Sandoz 58-035 was used to induce simultaneous activation of unfolded protein response (UPR) and pattern recognition receptors (PRRs) in mouse peritoneal macrophages.3
Biochem/physiol Actions
Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
Sandoz 58-035 inhibits the accumulation of cholesteryl esters and inhibits the esterification of cholesterol by 95% in arterial smooth muscle cells in culture.1 It does not affect the triglyceride metabolism by the gut.2
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Shizuya Yamashita et al.
Journal of clinical lipidology, 12(5), 1267-1279 (2018-08-06)
Cardiovascular risk is negatively correlated with cholesterol efflux capacity (CEC) from macrophages to high-density lipoproteins (HDLs) and positively correlated with fasting and nonfasting triglyceride-rich lipoproteins (TRLs). Pemafibrate, a novel selective peroxisome proliferator-activated receptor α modulator, robustly decreases the fasting TRL
Hiroshi Hirata et al.
The Journal of nutritional biochemistry, 47, 29-34 (2017-05-16)
Xanthohumol, a prominent prenyl flavonoid from the hop plant (Humulus lupulus L.), is suggested to be antiatherogenic since it reportedly increases high-density lipoprotein (HDL) cholesterol levels. It is not clear whether xanthohumol promotes reverse cholesterol transport (RCT), the most important
Julia T Stadler et al.
Biomedicines, 9(3) (2021-03-07)
Obesity increases the risk of coronary heart disease, partly due to its strong association with atherogenic dyslipidemia, characterized by high triglycerides and low high-density lipoprotein (HDL) cholesterol levels. Functional impairment of HDL may contribute to the increased cardiovascular mortality, but