S7389
SB-269970 塩酸塩
powder, ≥98% (HPLC)
別名:
(R)-3-[2-[2-(4-メチルピペリジン-1-イル)エチル]ピロリジン-1-スルホニル]フェノール 塩酸塩, SB 269970A
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この商品について
実験式（ヒル表記法）:
C18H28N2O3S · HCl
CAS番号:
分子量:
388.95
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D 75 to 90°, c = 1.0 in DMSO
storage condition
desiccated
solubility
H2O: 10 mg/mL, clear (warmed to 60 °C)
storage temp.
2-8°C
SMILES string
Cl.CC1CCN(CC1)CC[C@H]2CCCN2S(=O)(=O)c3cccc(O)c3
InChI
1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1
InChI key
XQCJOYZLWFNDIO-PKLMIRHRSA-N
Gene Information
human ... HTR7(3363)
Application
SB-269970 hydrochloride has been used to study the effect of different endotype combination on the activity of the 5-hydroxytryptamine receptor of tall fescue alkaloids. It has also been used to inhibit dopamine receptor signaling, in order to study its role in early hemocyte activation.
SB-269970 was used to study the role of 5-HT7 receptors in serotonin-induced hypothermia in rodents.6
Biochem/physiol Actions
5-HT7 セロトニンレセプタ-の選択的アンタゴニスト。
SB-269970 is an anti-psychotic agent that shows high affinity for 5-HT7 receptors. It may be effective in treating cognitive disabilities and schizophrenia-like deficits.4 SB-269970 desensitizes and decreases the excitatory effects of 5-HT7 receptors in rat hippocampus.5
Legal Information
GlaxoSmithKline Pharmaceuticalsの許諾を得て販売を行っています。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)