D1944
D4476
≥98% (HPLC), solid
別名:
4-(4-(2,3-ジヒドロベンゾ[1,4]ジオキシン-6-イル)-5-ピリジン-2-イル-1H-イミダゾール-2-イル)ベンズアミド
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この商品について
実験式（ヒル表記法）:
C23H18N4O3
CAS番号:
分子量:
398.41
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
assay
≥98% (HPLC)
form
solid
color
light yellow
solubility
DMSO: ~20 mg/mL, H2O: insoluble
originator
GlaxoSmithKline
storage temp.
2-8°C
SMILES string
NC(=O)c1ccc(cc1)-c2nc(-c3ccccn3)c([nH]2)-c4ccc5OCCOc5c4
InChI
1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)
InChI key
DPDZHVCKYBCJHW-UHFFFAOYSA-N
Application
D4476 has been used as a casein kinase I inhibitor (CKI) in various experiments.
Biochem/physiol Actions
D4476 may prevent or enhance apoptosis. It triggers tumor suppressor p53 and impairs transcription factor E2F-1.
D4476はCK1(カゼインキナ-ゼ1)に対する強力かつ選択的なATP競合的インヒビタ-です。
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)