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MMP Inhibitor I

Name: MMP Inhibitor I
Brand: MM

The MMP Inhibitor I controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sinónimos:

MMP Inhibitor I, FN-439

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Fórmula empírica (notación de Hill):

C₂₃H₃₄N₆O₆

Peso molecular:

490.55

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze

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Propiedades

Quality Segment

100

assay

≥95% (HPLC)

form

solid

potency

1 μM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

Descripción

General description

A tetrapeptidyl hydroxamic acid that inhibits interstitial and granulocyte collagenases (MMP-1 and MMP-8; IC₅₀ = 1 µM), granulocyte gelatinase (MMP-9; IC₅₀ = 30 µM), adn skin fibroblast stromelysin (MMP-3; IC₅₀ = 150 µM). Retains its activity even after prolonged incubation with PRONASE Protease (Cat. No. 53702) or human neutrophil elastase.

Biochem/physiol Actions

Cell permeable: no

Primary Target
MMP-1, MMP-8

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]

Hagemamn, T., et al. 2004. Carcinogenesis25, 1543.
Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c