D7408
2′,5′-Dideoxyadenosine
≥95% (HPLC), Adenylyl cyclase inhibitor, solid
Sinónimos:
2ʹ,5ʹ-dd-Ado, NSC 95943
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About This Item
Fórmula empírica (notación de Hill):
C10H13N5O2
Número CAS:
Peso molecular:
235.24
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Nombre del producto
2′,5′-Dideoxyadenosine, ≥95% (HPLC), solid
SMILES string
C[C@H]1O[C@H](C[C@@H]1O)n2cnc3c(N)ncnc23
InChI key
FFHPXOJTVQDVMO-DSYKOEDSSA-N
InChI
1S/C10H13N5O2/c1-5-6(16)2-7(17-5)15-4-14-8-9(11)12-3-13-10(8)15/h3-7,16H,2H2,1H3,(H2,11,12,13)/t5-,6+,7-/m1/s1
assay
≥95% (HPLC)
form
solid
color
white
solubility
DMSO: soluble
storage temp.
−20°C
Quality Level
Gene Information
rat ... Adcy2(81636)
Categorías relacionadas
Application
2′,5′-Dideoxyadenosine has been used to elucidate the mechanism of diligustilide (DLG). It has also been used to inhibit adenylate cyclase (AC).
Biochem/physiol Actions
Cell-permeable adenylyl cyclase inhibitor. IC50 = 2.7 μM in detergent-dispersed rat brain preparations.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
Store at −20 °C after reconstitution.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Journal of cellular physiology, 210(1), 99-110 (2006-09-26)
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In addition to a bicarbonate-regulated soluble adenylyl cyclase (sAC), mammalian spermatozoa, like somatic cells, appear to contain receptor/G protein-regulated AC activity that contributes to the modulation of specialized cell processes. This study provides evidence that agents, known to influence somatic
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