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361561 GSK-3 Substrate

GSK-3 Substrate MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PGS-1 Peptide

361561
  
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Overview

Replacement Information
Description
Overview

This product has been discontinued.





A synthetic peptide that can be used as an excellent substrate for glycogen synthase kinase-3α/β (GSK-3α/β) in in vitro kinase assays. The peptide sequence is derived from human muscle glycogen synthase 1 (amino acids 636-661).
Catalogue Number361561
Brand Family Calbiochem®
SynonymsPGS-1 Peptide
References
ReferencesIlouz, R., et al. 2006.J. Biol. Chem. 281, 30621. Sutherland, C., et al. 1993. Biochem. J. 296, 15.
Product Information
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₂₃H₁₉₁N₄₀O₄₈P
Chemical formulaC₁₂₃H₁₉₁N₄₀O₄₈P
Hygroscopic Hygroscopic
Applications
Application CommentsReconstitute 1 mg of the substrate in 1.3 ml DI water resulting in a 250 µM solution recommended for GSK-3 assays
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Peptide SequenceH-Tyr-Arg-Arg-Ala-Ala-Val-Pro-Pro-Ser-Pro-Ser-Leu-Ser-Arg-His-Ser-Ser-Pro-His-Gln-pSer-Glu-Asp-Glu-Glu-Glu-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
361561 0

Documentation

GSK-3 Substrate Certificates of Analysis

TitleLot Number
361561

References

Reference overview
Ilouz, R., et al. 2006.J. Biol. Chem. 281, 30621. Sutherland, C., et al. 1993. Biochem. J. 296, 15.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2009 RFH
SynonymsPGS-1 Peptide
DescriptionA synthetic peptide that contains the glycogen synthase kinase-3 (GSK-3) recognition motif S-X-X-X-S(p) and serves as an excellent GSK-3α/β substrate in in vitro kinase assays. The peptide sequence is derived from the highly conserved GSK phosphorylation site in glycogen synthase 1 of multiple species, including human, mouse, rat, dog, cow, pig, rabbit, and horse. The totally non-phosphorylated peptide cannot be recognized by and is therefore not a substrate for GSK-3.
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₂₃H₁₉₁N₄₀O₄₈P
Peptide SequenceH-Tyr-Arg-Arg-Ala-Ala-Val-Pro-Pro-Ser-Pro-Ser-Leu-Ser-Arg-His-Ser-Ser-Pro-His-Gln-pSer-Glu-Asp-Glu-Glu-Glu-OH
Purity≥95% by HPLC
SolubilityH₂O (1 mg/ml)
CommentsReconstitute 1 mg of the substrate in 1.3 ml DI water resulting in a 250 µM solution recommended for GSK-3 assays
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesIlouz, R., et al. 2006.J. Biol. Chem. 281, 30621. Sutherland, C., et al. 1993. Biochem. J. 296, 15.