8.51027
Biotin-ONp
Novabiochem®
Synonym(s):
Biotin-ONp, Biotin p-nitrophenyl ester,5-(2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid p-nitrophenyl ester
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About This Item
Product Name
Biotin-ONp, Novabiochem®
SMILES string
S1[C@H]([C@H]3NC(=O)N[C@H]3C1)CCCCC(=O)Oc2ccc(cc2)[N+](=O)[O-]
InChI
1S/C16H19N3O5S/c20-14(24-11-7-5-10(6-8-11)19(22)23)4-2-1-3-13-15-12(9-25-13)17-16(21)18-15/h5-8,12-13,15H,1-4,9H2,(H2,17,18,21)/t12-,13-,15-/m0/s1
InChI key
YUDNXDTXQPYKCA-YDHLFZDLSA-N
product line
Novabiochem®
assay
≥97.0% (HPLC)
≥98% (TLC)
form
powder
reaction suitability
reaction type: Biotinylations
manufacturer/tradename
Novabiochem®
mp
163-165 °C
application(s)
peptide synthesis
storage temp.
15-25°C
Quality Level
Analysis Note
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in dioxan): +34.5 - +39.5 °
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
To see the solvent systems used for TLC of Novabiochem® products please click here.
Application
- Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation: This study discusses the synthesis and applications of cell-permeant peptides involving biotin-ONP for enhanced cellular processes (Almansour, 2017).
- Structure-function analysis of tight junction-directed permeation enhancer PIP250: Provides insights into the utility of biotin-ONP in analyzing the structure and function of peptides used to enhance cellular permeation (Taverner et al., 2023).
General description
Associated Protocols and Technical Articles
Biotinylation Reagents for Peptide Synthesis
Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)
Literature references
[1] B. Baumeister, et al. Int. J. Pept. Res. Ther., 11, 139.
[2] D. Winkler & P. McGeer (2008) Proteomics, 8, 961.
Other Notes
Legal Information
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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