A0752

Adenosine 5′-diphosphoribose sodium salt

Name: Adenosine 5′-diphosphoribose sodium salt
Brand: SIGMA

≥93%, from yeast (candida utilis), powder

Synonyme(s) :

ADPR, ADP-Ribose

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About This Item

Formule empirique (notation de Hill) :

C₁₅H₂₃N₅O₁₄P₂

Numéro CAS:

68414-18-6

Poids moléculaire :

559.32

UNSPSC Code:

41106305

PubChem Substance ID:

24890449

NACRES:

NA.51

MDL number:

MFCD00136017

Nom du produit

Adenosine 5′-diphosphoribose sodium salt, ≥93%

SMILES string

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C3O

InChI

1S/C15H23N5O14P2.Na.H/c16-13-9-14(18-4-17-13)20(5-19-9)15-12(26)11(25)8(33-15)3-32-36(29,30)34-35(27,28)31-2-7(23)10(24)6(22)1-21;;/h1,4-8,10-12,15,22-26H,2-3H2,(H,27,28)(H,29,30)(H2,16,17,18);;

InChI key

NWPVXDZLQTURKI-UHFFFAOYSA-N

biological source

yeast (candida utilis)

assay

≥93%

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

Catégories apparentées

Biochemicals

Nucleosides and Nucleotides

Application

5′-Deoxy-5′-(methylthio)adenosine has been used:

to give a range of nicotinamide adenine dinucleotide (NADH)
oxidation rates for the respiratory complex (CI/CIII/CIV)
CI/alternative(AOX) pathway
to measure poly(ADP-ribose) glycohydrolaseactivity
poly(ADP-ribose) (PAR) binding competition assay
oxidase (AOX) pathway
to measure poly(ADP-ribose) glycohydrolase activity
poly(ADP-ribose) (PAR) binding competition assay

Biochem/physiol Actions

Adenosine5′-diphosphoribose (ADP-Ribose) is used as the basic building block used as a substrate in the formation of poly(ADP-ribose) by members of the poly(ADP-ribose) polymerase (PARP) family. Poly(ADP-ribose) formation and degradation are important components of DNA repair and apoptosis signaling. ADP-Ribose initiates the transient receptor potential subfamily melastatin, type2 (TRPM2), a Na⁺, Ca2⁺, and K⁺ cation channel.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Icariin protects against radiation-induced mortality and damage in vitro and in vivo.

Byung Kil Park et al.

International journal of radiation biology, 95(8), 1094-1102 (2019-03-05)

Purpose: The present study aimed to investigate the potential protective effects of icariin both in vivo and in vitro, an active flavonoid glucoside derived from medicinal herb Epimedium, and its possible mechanisms against radiation-induced injury. Methods: Male C57BL/6 mice were

Nrf2 Mediates the Anti-apoptotic and Anti-inflammatory Effects Induced by Gastrodin in Hydrogen Peroxide-Treated SH-SY5Y Cells.

Marcos Roberto de Oliveira et al.

Journal of molecular neuroscience : MN, 69(1), 115-122 (2019-05-28)

Redox impairment, inflammation, and increased rates of cell death are central players during neurodegeneration. In that context, activation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) has been viewed as an interesting strategy in order to reduce

Genetic and pharmacological inhibition of acid ceramidase prevents asymmetric cell division by neosis.

Shai White-Gilbertson et al.

Journal of lipid research, 60(7), 1225-1235 (2019-04-17)

Radiation treatment failure or relapse after initial response to chemotherapy presents significant clinical challenges in cancer patients. Escape from initial courses of treatment can involve reactivation of embryonic developmental stages, with the formation of polynuclear giant cancer cells (PGCCs). This

Mitochondrial supercomplexes do not enhance catalysis by quinone channeling

Fedor, Justin G and Hirst, Judy

Cell Metabolism, 28(3), 525-531 (2018)

Structure?Activity Relationship of Adenosine 5?-diphosphoribose at the Transient Receptor Potential Melastatin 2 (TRPM2) Channel: Rational Design of Antagonists

Moreau C, et al.

Journal of Medicinal Chemistry, 56(24) (2013)

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