G6776
ゲニステイン
From Glycine max (soybean), ~98% (HPLC), tyrosine protein kinase inhibitor, powder
別名:
4′,5,7-トリヒドロキシイソフラボン, 5,7-ジヒドロキシ-3-(4-ヒドロキシフェニル)-4H-1-ベンゾピラン-4-オン
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この商品について
実験式（ヒル表記法）:
C15H10O5
CAS番号:
分子量:
270.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
207-174-9
MDL number:
Beilstein/REAXYS Number:
263823
Assay:
~98% (HPLC)
Form:
powder
製品名
ゲニステイン, from Glycine max (soybean), ~98% (HPLC)
biological source
Glycine max (soybean)
Quality Segment
assay
~98% (HPLC)
form
powder
mp
>280 °C
solubility
DMSO: soluble, ethanol: soluble
storage temp.
−20°C
SMILES string
Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
InChI
1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
InChI key
TZBJGXHYKVUXJN-UHFFFAOYSA-N
Gene Information
human ... AKT1(207), CYP19A1(1588), EGFR(1956), ESR1(2099), ESR2(2100)
mouse ... Esr1(13982), Hexa(15211)
rat ... Adora1(29290), Adora2a(25369), Ar(24208)
General description
Genistein is a nutraceutical isoflavnoid from soybean and is a phytoestrogen. It is derived from genistin.
Application
Genistein has been used:
- as an anticancer agent to test its cytotoxicity in cervix adenocarcinoma cells
- as a polyphenol to test its effect on reactive oxygen species in mitochondria from sperm
- to test its radical scavenging effect on the UV irradiated in dermal and keloid fibroblasts
Biochem/physiol Actions
チロシンタンパク質キナ-ゼの阻害剤です。他のタンパク質キナ-ゼの反応においては、ATPの競合的阻害剤として作用します。抗血管新生剤であり、血管新生の調節に関与する遺伝子の転写をダウンレギュレ-トします。
Genistein has antioxidant functionality and is effective in quenching reactive oxygen species. It is beneficial to human health.
Features and Benefits
This compound is featured on the Met page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type N95 (US)