抗Sirt3抗体 ウサギ宿主抗体

Sirtuin 3 (Sirt3) is an NAD-dependent deacetylase localized to the mitochondrial matrix. SIRT3 encodes a 44 kDa full length form and a N-terminal 142 amino acids truncated form. It is mapped to human chromosome 11p15.5.

ヒトSIRT3のアミノ酸384~399に相当する合成ペプチド (N末端システイン付加) のKLH結合体。

Anti-Sirt3 antibody produced in rabbit has been used in western blotting.

Sirtuin 3 (Sirt3) is mainly a nuclear protein that transfers to the mitochondria during cellular stress. In humans, Sirt3 deacetylates and activates the mitochondrial enzyme acetyl-CoA synthetase 1 (AceCS2). Sirt3 is implicated in regulating mitochondrial function and thermogenesis in brown adipocytes. Its levels have been shown to correlate with extended life span. Increased levels of Sirt3 were associated with node positive breast cancer.

0.01 M PBS溶液 (pH 7.4, 15 mM アジ化ナトリウム含有)。

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