S4072
抗Sirt3抗体 ウサギ宿主抗体
affinity isolated antibody, buffered aqueous solution
別名:
抗SIR2L3抗体, 抗サーチュイン(silent mating type information regulation2ホモログ) 3 (S. cerevisiae) 抗体
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この商品について
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
14
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~28 kDa
species reactivity
human
technique(s)
indirect immunofluorescence: suitable, western blot: 2.5-5 μg/mL using human HepG2 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SIRT3(23410)
General description
Sirtuin 3 (Sirt3) is an NAD-dependent deacetylase localized to the mitochondrial matrix. SIRT3 encodes a 44 kDa full length form and a N-terminal 142 amino acids truncated form. It is mapped to human chromosome 11p15.5.
Immunogen
ヒトSIRT3のアミノ酸384~399に相当する合成ペプチド (N末端システイン付加) のKLH結合体。
Application
Anti-Sirt3 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Sirtuin 3 (Sirt3) is mainly a nuclear protein that transfers to the mitochondria during cellular stress. In humans, Sirt3 deacetylates and activates the mitochondrial enzyme acetyl-CoA synthetase 1 (AceCS2). Sirt3 is implicated in regulating mitochondrial function and thermogenesis in brown adipocytes. Its levels have been shown to correlate with extended life span. Increased levels of Sirt3 were associated with node positive breast cancer.
Physical form
0.01 M PBS溶液 (pH 7.4, 15 mM アジ化ナトリウム含有)。
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
IXO14266: + S4072-BULK: + S4072-25UL: + S4072-200UL: + S4072-VAR:
jan
Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13
Bellizzi D, et al.
Genomics, 89(1), 143-150 (2007)
Jing Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(12), 4418-4431 (2014-03-22)
Modern society enables a shortening of sleep times, yet long-term consequences of extended wakefulness on the brain are largely unknown. Essential for optimal alertness, locus ceruleus neurons (LCns) are metabolically active neurons that fire at increased rates across sustained wakefulness.
SIRT3: oncogene and tumor suppressor in cancer
Torrens-Mas M, et al.
Cancers, 9(7), 90-90 (2017)
SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
Scher MB, et al.
Genes & Development, 21(8), 920-928 (2007)
Komuraiah Myakala et al.
The Journal of biological chemistry, 299(8), 104975-104975 (2023-07-11)
Diabetes mellitus is the leading cause of cardiovascular and renal disease in the United -States. Despite the beneficial interventions available for patients with diabetes, there remains a need for additional therapeutic targets and therapies in diabetic kidney disease (DKD). Inflammation
関連コンテンツ
Instructions
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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