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Merck

233412

Ethyl (hydroxyimino)cyanoacetate

97%, for peptide synthesis

Synonyme(s) :

Ethyl cyano(hydroxyimino)acetate, Ethyl cyanoglyoxalate-2-oxime, Ethyl isonitrosocyanoacetate

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A propos de cet article

Formule linéaire :
NCC(=NOH)CO2C2H5
Numéro CAS:
Poids moléculaire :
142.11
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
223-351-3
MDL number:
Beilstein/REAXYS Number:
774783
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Nom du produit

Ethyl (hydroxyimino)cyanoacetate, 97%

InChI key

LCFXLZAXGXOXAP-QPJJXVBHSA-N

InChI

1S/C5H6N2O3/c1-2-10-5(8)4(3-6)7-9/h9H,2H2,1H3/b7-4+

SMILES string

CCOC(=O)C(=N\O)\C#N

assay

97%

form

solid

Quality Level

mp

130-132 °C (lit.)

application(s)

peptide synthesis

functional group

amine, ester, nitrile, oxime

General description

Ethyl (hydroxyimino)cyanoacetate is a potential replacement for zobenzotriazole and benzotriazole derivatives used in peptide synthesis.

Ethyl (hydroxyimino)cyanoacetate is also called as Oxyma. It is a highly efficient greener alternative for the amide and peptide synthesis.

Application

Ethyl (hydroxyimino)cyanoacetate has been used as an additive for the carbodiimide-mediated amide bond formation during established peptide synthesis method.For peptide synthesis grade material, please see product 851086.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Consulter la Bibliothèque de documents

Alvin W Hung et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(17), 6799-6804 (2011-04-13)
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Doaa M Anwar et al.
Bioconjugate chemistry, 29(9), 3026-3041 (2018-08-16)
In this study, promising approaches of dual-targeted micelles and drug-polymer conjugation were combined to enable injection of poorly soluble anticancer drugs together with site-specific drug release. Ursodeoxycholic acid (UDCA) as a hepatoprotective agent was grafted to maltodextrin (MD) via carbodiimide
Valeria Tarallo et al.
International journal of molecular sciences, 21(2) (2020-01-16)
Age-related macular degeneration (AMD) is the primary cause of blindness in advanced countries. Repeated intravitreal delivery of anti-vascular endothelial growth factor (VEGF) agents has represented an important advancement for the therapy of wet AMD with significative results in terms of
Miriam Reverter et al.
Metabolites, 10(6) (2020-06-04)
Understanding natural defense mechanisms against parasites can be a valuable tool for the development of innovative therapies. We have previously identified a butterflyfish species (Chaetodonlunulatus) that avoids gill monogenean parasites while living amongst closely related parasitized species. The metabolome and
Ranko Gacesa et al.
International journal of molecular sciences, 21(20) (2020-10-16)
Siderophores are iron-complexing compounds synthesized by bacteria and fungi. They are low molecular weight compounds (500-1500 Daltons) possessing high affinity for iron(III). Since 1970 a large number of siderophores have been characterized, the majority using hydroxamate or catecholate as functional

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