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Merck

H-125

5beta/6beta-Hydroxy Lurasidone (Mixture of Diastereomers) solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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A propos de cet article

Formule empirique (notation de Hill) :
C28H36N4O3S
Poids moléculaire :
508.68
NACRES:
NA.24
UNSPSC Code:
41116107
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grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

Quality Level

General description

Hydroxylurasidone is the most abundant metabolite of lurasidone in urine. Lurasidone, marketed under the trade name Latuda®, is a new atypical antipsychotic developed for the treatment of schizophrenia and episodes of depression in adults with bipolar disorder (manic depression). A certified solution standard suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, pharmaceutical research, or urine drug testing.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Latuda is a registered trademark of Dainippon Sumitomo Pharma Co., Ltd.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Classe de stockage

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Christina J Matheny et al.
Chemistry & biology, 20(11), 1352-1363 (2013-11-05)
Phenotypic high-throughput chemical screens allow for discovery of small molecules that modulate complex phenotypes and provide lead compounds for novel therapies; however, identification of the mechanistically relevant targets remains a major experimental challenge. We report the application of sequential unbiased
Eleonora Lapi et al.
Molecular cell, 32(6), 803-814 (2008-12-30)
p73 has been identified as a structural and functional homolog of the tumor suppressor p53. The transcriptional coactivator Yes-associated protein (YAP) has been demonstrated to interact with and to enhance p73-dependent apoptosis in response to DNA damage. Here, we show
Kenneth D Harrison et al.
The EMBO journal, 30(12), 2490-2500 (2011-05-17)
Dolichol monophosphate (Dol-P) functions as an obligate glycosyl carrier lipid in protein glycosylation reactions. Dol-P is synthesized by the successive condensation of isopentenyl diphosphate (IPP), with farnesyl diphosphate catalysed by a cis-isoprenyltransferase (cis-IPTase) activity. Despite the recognition of cis-IPTase activity
Peng Wang et al.
Nature medicine, 21(4), 383-388 (2015-03-10)
Types 1 and 2 diabetes affect some 380 million people worldwide. Both ultimately result from a deficiency of functional pancreatic insulin-producing beta cells. Beta cells proliferate in humans during a brief temporal window beginning around the time of birth, with
Cristin D Davidson et al.
Annals of clinical and translational neurology, 3(5), 366-380 (2016-05-28)
Niemann-Pick type C (NPC) disease is a fatal, neurodegenerative, lysosomal storage disorder characterized by intracellular accumulation of unesterified cholesterol (UC) and other lipids. While its mechanism of action remains unresolved, administration of 2-hydroxypropyl-β-cyclodextrin (HPβCD) has provided the greatest disease amelioration

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