Accéder au contenu
Merck

171610

Anti-Amyloid Precursor Protein, C-Terminal (751-770) Rabbit pAb

liquid, Calbiochem®

Synonyme(s) :

Anti-0443, Anti-APP-CT20

Se connecter pour consulter les tarifs organisationnels et contractuels.

Sélectionner une taille de conditionnement

A propos de cet article

NACRES:
NA.43
UNSPSC Code:
12352203
Clone:
polyclonal
Species reactivity:
human
Application:
—
Citations:
51

Principaux documents

Voir toute la documentation
Service technique
Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.
Laissez-nous vous aider
Service technique
Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.
Laissez-nous vous aider

biological source

rabbit

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

form

liquid

species reactivity

human

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

dilution

(Immunoblotting (1:5000-1:20,000)
Immunofluorescence (1:1000)
Immunohistochemistry (1:1000)
Immunoprecipitation (1:1000))

isotype

IgG

shipped in

ambient

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Catégories apparentées

General description

Anti-Amyloid Precursor Protein, C-Terminal (751-770), rabbit polyclonal, recognizes full-length APP and C-terminal soluble products CTFα, β, and γ. It is validated for WB, IF, IHC, and IP.
Rabbit polyclonal antibody supplied as undiluted serum. Recognizes full-length APP and C-terminal soluble products CTFγ (~6 kDa), CTFα (~9 kDa), and CTFβ (~11 kDa).
Recognizes full-length APP and C-terminal soluble products CTFγ (~6 kDa), CTFα (~9 kDa), and CTFβ (~11 kDa).
  • Antibody Target Gene Symbol: APP
  • Target Synonym: AAA, AD1, Adap, AL024401, Amyloid precursor, Amyloidogenic glycoprotein, APP isoform 1, APPI, appican, CTFgamma, CVAP, E030013M08RIK, Nexin II, P3, PN2, PreA4, PROTEASE NEXIN2
  • Entrez Gene Name: amyloid beta (A4) precursor protein
  • Hu Entrez ID: 351 (Related Antibodies: PC729, PC152,PC151, PC150, PC149, NE1012,171609, 171608, 171607, 171606, 171605, 171604, 171603, 171598, 171537)
  • Mu Entrez ID: 11820
  • Rat Entrez ID: 54226

    • Immunogen

    Human
    a synthetic peptide [(C)KMQQNGYENPTYKFFEQMQN] corresponding to amino acids 751-770 of human precursor protein (APP), conjugated to KLH

    Application

    Immunoblotting (1:5000-1:20,000)

    Immunofluorescence (1:1000)

    Immunohistochemistry (1:1000)

    Immunoprecipitation (1:1000)

    Preparation Note

    Following initial thaw, aliquot and freeze (-20°C).

    Other Notes

    Pinnix, I., et al. 2001. J. Biol. Chem.276, 481.
    Variables associated with assay conditions will dictate the proper working dilution.

    Legal Information

    Purchase of this material is for research use only. Users are invited to request a license from Mayo prior to using the 0433 antibody or any derivatives for clinical diagnostic or therapeutic purposes. For license information, please contact: Mayo Medical Ventures, Office of Technology Commercialization (507) 284-8878, 200 First Street SW, Rochester, MN 55905-001.
    CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

    Disclaimer

    Toxicity: Standard Handling (A)

    Vous ne trouvez pas le bon produit ?  

    Essayez notre Outil de sélection de produits.

    Classe de stockage

    10 - Combustible liquids

    wgk

    WGK 1

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

    Certificats d'analyse (COA)

    Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

    Déjà en possession de ce produit ?

    Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

    Consulter la Bibliothèque de documents

    Dario Tejera et al.
    The EMBO journal, 38(17), e101064-e101064 (2019-07-31)
    Alzheimer's disease is the most prevalent type of dementia and is caused by the deposition of extracellular amyloid-beta and abnormal tau phosphorylation. Neuroinflammation has emerged as an additional pathological component. Microglia, representing the brain's major innate immune cells, play an
    Yang Xiang et al.
    Acta neuropathologica, 130(4), 487-499 (2015-09-14)
    Amyloid-beta (Aβ) plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). The physiological capacity of peripheral tissues and organs in clearing brain-derived Aβ and its therapeutic potential for AD remains largely unknown. Here, we measured blood Aβ levels
    Vincent J Mecozzi et al.
    Nature chemical biology, 10(6), 443-449 (2014-04-22)
    Retromer is a multiprotein complex that trafficks cargo out of endosomes. The neuronal retromer traffics the amyloid-precursor protein (APP) away from endosomes, a site where APP is cleaved into pathogenic fragments in Alzheimer's disease. Here we determined whether pharmacological chaperones
    Ramon Velazquez et al.
    Molecular psychiatry, 25(10), 2620-2629 (2019-01-10)
    The lack of effective treatments for Alzheimer's disease (AD) is alarming, considering the number of people currently affected by this disorder and the projected increase over the next few decades. Elevated homocysteine (Hcy) levels double the risk of developing AD.
    Inderjeet Saluja et al.
    Neurobiology of disease, 36(1), 162-168 (2009-07-28)
    The neuronal adaptor protein X11alpha/mint-1/APBA-1 binds to the cytoplasmic domain of the amyloid precursor protein (APP) to modulate its trafficking and metabolism. We investigated the consequences of reducing X11alpha in a mouse model of Alzheimer's disease (AD). We crossed hAPPswe/PS-1DeltaE9
    Afficher tous les articles scientifiques apparentés

    Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

    Contacter notre Service technique