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251680

Dantrolene sodium salt

≥95% (HPLC), Ryanodine receptor blocker, solid

Synonyme(s) :

Dantrolene, Sodium Salt

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A propos de cet article

Formule empirique (notation de Hill) :
C14H9N4O5 · Na
Numéro CAS:
14663-23-1
Poids moléculaire :
336.23
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00079130
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic)
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Nom du produit

Dantrolene, Sodium Salt, A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor.

Quality Level

100

description

Merck USA index - 14, 2816

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic)

color

orange

solubility

DMSO: 3 mg/mL, aqueous base: soluble

shipped in

ambient

storage temp.

10-30°C

SMILES string

[Na]N1C(=O)N(CC1=O)\N=C\c2[o]c(cc2)c3ccc(cc3)[N+](=O)[O-]

InChI

1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;

InChI key

KSRLIXGNPXAZHD-HAZZGOGXSA-M

General description

A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor. Inhibits long-term depression and depotentiation of synaptic transmission. Has neuroprotective effects in cases of cerebral ischemia.
A skeletal muscle relaxant. Blocks intracellular calcium release from the sarcoplasmic reticulum during excitation-contraction coupling by binding to the ryanodine receptor. Blocks long-term depression and depotentiation.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Ryanodine receptor
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Wei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.
O’Mara, S.M., et al. 1995. Neuroscience68, 621.
Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem.270, 18465.
Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.
Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA91, 3039.
Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA91, 3039.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Classe de stockage

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

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Calcific aortic valve disease (CAVD), a fibrocalcific thickening of the aortic valve leaflets causing obstruction of the left ventricular outflow tract, affects nearly 10 million people worldwide. For those who reach end-stage CAVD, the only treatment is highly invasive valve
Joseph E Pick et al.
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