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489350

L-(−)-Norepinephrine (+)-bitartrate salt monohydrate

≥97% (LC/MS), α,β-Adrenergic agonist, crystalline solid

Synonyme(s) :

L-(−)-Norepinephrine-(+)-bitartrate salt monohydrate, R(–)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol-(+)-tartrate, Noradrenaline

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A propos de cet article

Formule empirique (notation de Hill) :
C8H11NO3 · C4H6O6 · H2O
Numéro CAS:
108341-18-0
Poids moléculaire :
337.28
MDL number:
MFCD00150449
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (LC/MS)
Form:
crystalline solid
Quality level:
100
Storage condition:
OK to freeze, desiccated
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Nom du produit

L-(–)-Norepinephrine-(+)-bitartrate, α,β-Adrenergic agonist.

Quality Level

100

description

Merck USA index - 14, 6695

assay

≥97% (LC/MS)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

NC[C@H](O)c1cc(c(cc1)O)O.O[C@H]([C@@H](O)C(=O)O)C(=O)O.O

InChI

1S/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1

InChI key

LNBCGLZYLJMGKP-LUDZCAPTSA-N

General description

α,β-Adrenergic agonist. A vasoconstrictive agent that causes down-regulation of angiotensin II receptors. Oxidation sensitive.

Biochem/physiol Actions

Cell permeable: no
Primary Target
α,β-Adrenergic agonist
Product does not compete with ATP.
Reversible: no

Preparation Note

Addition of sodium bisulfite (at a final concentration of 0.1%) is necessary to prevent oxidation.
Following reconstituiton, refrigerate (4°C). Stock solutions are stable for up to 5 days at 4°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Yang, H., et al. 1996. Hypertension 27, 1277.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

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Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Oral

Classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

H Yang et al.
Hypertension (Dallas, Tex. : 1979), 27(6), 1277-1283 (1996-06-01)
Norepinephrine causes downregulation of angiotensin II (Ang II) receptors in Wistar-Kyoto rat (WKY) brain neuronal cultures. The aim of this study was to compare the cross talk between Ang II and alpha1-adrenergic receptors in these neuronal cultures. Norepinephrine causes a
Inbal Rachmin et al.
Experimental dermatology, 30(4), 578-587 (2021-02-19)
Hair greying depends on the altered presence and functionality of hair follicle melanocytes. Melanocyte stem cells (MelSCs) reside in the bulge of hair follicles and give rise to migrating and differentiating progeny during the anagen phase. Ageing, genotoxic stress, redox