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Merck

567540

Sodium Orthovanadate

A broad spectrum potent inhibitor of protein tyrosine phosphatases.

Synonyme(s) :

Sodium Orthovanadate, PTP Inhibitor X

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A propos de cet article

Formule empirique (notation de Hill) :
Na3O4V
Numéro CAS:
13721-39-6
Poids moléculaire :
183.91
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00003511

Principaux documents

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Nom du produit

Sodium Orthovanadate, A broad spectrum potent inhibitor of protein tyrosine phosphatases.

SMILES string

[V](=O)([O-])([O-])[O-].[Na+].[Na+].[Na+]

InChI

1S/3Na.4O.V/q3*+1;;3*-1;

InChI key

IHIXIJGXTJIKRB-UHFFFAOYSA-N

description

RTECS - YW1120000

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
Na+,K+-ATPase, acid , alkaline phosphatases, phosphofructokinase, and adenylate kinase
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Harmful (C)

General description

A broad spectrum potent inhibitor of protein tyrosine phosphatases. Also known to inhibit Na+/K+ ATPase, acid and alkaline phosphatases, phosphofructokinase, and adenylate kinase. Most recently shown to inhibit ATPase activity of the reconstituted binding protein-dependent ATP-Binding Cassette (ABC) transporter for maltose (MalFGK2) of Salmonella typhimurium in the micromolar range. Can be converted to pervanadate by hydrogen peroxide.

Other Notes

Huyer, G., et al. 1997. J. Biol. Chem. 272, 843.
Hunke, S., et al. 1995. Biochem. Biophys. Res. Commun.216, 589.
Levchuck, S.G., et al. 1994. Pediatric Res.37, 382A.
Fohr, K.J., et al. 1989. Biochem. J.262, 83.
Swarup, G., et al. 1982. Biochem. Biophys. Res. Commun.107, 1104.
Seargeant, L.E. and Stinson, R.A. 1979. Biochem. J.181, 247.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Classe de stockage

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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